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 > 【PDGF-BB】重组蛋白信息

PDGF-BB信息

英文名称:Platelet-derived growth factor subunit B
中文名称:血小板衍生生长因子B亚基
靶点别称:Epididymis Secretory Sperm Binding Protein,Becaplermin,PDGF-2,PDGFB,Platelet Derived Growth Factor Subunit B,Platelet-Derived Growth Factor Beta Polypeptide (Simian Sarcoma Viral (V-Sis) Oncogene Homolog),Platelet-Derived Growth Factor B Chain,Proto-Oncog
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

PDGF-BB产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
PDB-H5127
Human
Unconjugated Human PDGF-BB Protein, His,Avitag
PDB-H4112
Human
Human PDGF-BB Protein, Tag Free
 
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PDGF-BB Molecule Synonym Name

PDGF-BB,PDGF-B,FLJ12858,PDGF2,SIS,SSV,c-sis

PDGF-BB 分子背景

PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

PDGF-BB 参考文献

PDGF-BB临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
KUR-212 KUR-212; I-020502 临床二期 Kuros Biosciences 烧伤 详情
HL-217 HL-217; KR-31831 临床一期 韩国化学研究所 年龄相关性黄斑变性 详情
SHP-627 FT-11; FT-001; FT-011; SHP-627 临床二期 Shire Pharmaceuticals 系统性硬皮病, 青光眼, 弥漫性硬皮病 详情

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