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Integrin alpha 2 beta 1信息

英文名称:Integrin alpha2/beta1
中文名称:整合素α-2/β-1复合体
靶点别称:Integrin alpha2beta1
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

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Integrin alpha 2 beta 1 Molecule Synonym Name

Integrin alpha 2 beta 1,ITGA2 & ITGB1

Integrin alpha 2 beta 1 分子背景

Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.

Integrin alpha 2 beta 1 参考文献

Integrin alpha 2 beta 1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Risuteganib ALG-1001 临床二期 Allegro Ophthalmics 视网膜病变, 糖尿病黄斑水肿, 糖尿病视网膜病变, 年龄相关性黄斑变性 详情

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