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FGF basic信息

英文名称:Fibroblast growth factor 2
中文名称:成纤维细胞生长因子2
靶点别称:FGF-2,Heparin-binding growth factor 2,Basic fibroblast growth factor,FGFB,bFGF,HBGF-2,FGF2,Fibroblast Growth Factor 2 (Basic),Basic Fibroblast Growth Factor BFGF,Prostatropin,Fibroblast Growth Factor 2
上市药物数量:2
临床药物数量:3
最高研发阶段:批准上市

FGF basic产品列表

 
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FGF basic 分子别名

FGF2,BFGF,FGFB,FGF basic,HBGF-2

FGF basic 分子背景

FGF basic is a member of the FGF family of at least 23 related mitogenic proteins which show 35-60% amino acid conservation. FGF acidic and basic, unlike the other members of the family, lack signal peptides and are apparently secreted by mechanisms other than the classical protein secretion pathway. FGF basic has been isolated from a number of sources, including neural tissue, pituitary, adrenal cortex, corpus luteum, and placenta. This factor contains four cysteine residues, but reduced FGF basic retains full biological activity, indicating that disulfide bonds are not required for this activity. bFGF is a critical component of human embryonic stem cell culture medium; the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins. It is necessary in mouse-feeder cell dependent culture systems, as well as in feeder and serum-free culture systems.

FGF basic 前沿进展

FGF basic上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Thalidomide 沙利度胺 NSC-66847; NSC-527179; K-17; VP-02 批准上市 Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan 麻风结节性红斑 Fujimoto Pharmaceutical 1982-01-01 HIV感染, 强直性脊柱炎, 骨髓增生异常综合征, 特发性肺纤维化, 多发性骨髓瘤, HIV消耗综合征, 结节性红斑, 麻风结节性红斑, 肝细胞癌 详情
Pentosan Polysulfate Sodium 木聚硫钠 PPS; PZ-68; SP-54; AK-150 批准上市 Ivax, 梯瓦 Elmiron, Zilosul EU 间质性膀胱炎 Bene-Arzneimittel Gmbh 1996-09-26 疼痛, 膝关节炎, 间质性膀胱炎, 前列腺炎 详情

FGF basic临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Muparfostat sodium PI-88 临床三期 澳洲国立大学 肝癌, 实体瘤, 前列腺癌, 肺癌, 肝细胞癌, 黑色素瘤, 非小细胞肺癌 详情
RBM-007 RBM-007; ID3 (21); APT-F2 临床二期 Ribomic 年龄相关性黄斑变性 详情
Fibroblast growth factor 2 gene therapy (ID Pharma) SeV-10101; SEV-10101; DVC-10101; BF-30 临床二期 Dnavec 动脉闭塞性疾病, 缺血, 外周动脉疾病 详情

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