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 > 【GFR alpha-like】

GFR alpha-like信息

英文名称:GDNF family receptor alpha-like
中文名称
靶点别称
上市药物数量:0
临床药物数量:0
最高研发阶段:终止

抗体项目交易平台

项目名称 项目阶段 分子类型 分子来源 疾病领域 适应症
GFRAL mAb - 01 IND 单抗 鼠源人源化 代谢调节 恶液质

GFR alpha-like分子别名

GFR alpha like,GFR alpha-like,GFRAL,GRAL

GFR alpha-like分子背景

GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

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