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LAP (TGF-beta 1)信息

英文名称:Transforming growth factor beta 1
中文名称:转化生长因子β1
靶点别称:TGFbeta,Transforming Growth Factor Beta 1,Diaphyseal Dysplasia 1, Progressive,TGF-Beta1,IBDIMDE,Transforming Growth Factor beta1,Latency-Associated Peptide,TGFB,CED,DPD1,Transforming Growth Factor, Beta 1,TGF-Beta-1,Prepro-Transforming Growth Factor Beta-
上市药物数量:1
临床药物数量:10
最高研发阶段:批准上市

LAP (TGF-beta 1)产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
LAP-H5245
Human
Human LAP (TGF-beta 1) Protein, His Tag
LAP-H82Q6
Human
Biotinylated Human LAP (TGF-beta 1) Protein, His,Avitag™ (MALS verified)
LAP-H5213
Human
Human LAP (TGF-beta 1) Protein, Tag Free
 
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LAP (TGF-beta 1) 分子别名

LAP (TGF-beta 1),LAP (TGFB1),TGFB1,CED,DPD1,LAP,TGF-beta-1,TGFB

LAP (TGF-beta 1) 分子背景

Transforming growth factor beta 1 ( TGFB1) is also known as TGF-β1, CED, DPD1, TGFB. is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The TGFB1 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). The TGFB1 protein is found throughout the body and plays a role in development before birth, the formation of blood vessels, the regulation of muscle tissue and body fat development, wound healing, and immune system function. TGFB1 is particularly abundant in tissues that make up the skeleton, where it helps regulate bone growth, and in the intricate lattice that forms in the spaces between cells (the extracellular matrix). Within cells, this protein is turned off (inactive) until it receives a chemical signal to become active. TGFB1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGFB1. TGFB1 has been shown to interact with TGF beta receptor 1, LTBP1, YWHAE, EIF3I and Decorin.

LAP (TGF-beta 1) 前沿进展

LAP (TGF-beta 1)上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Pirfenidone 吡非尼酮 F-647; AMR-69; GP-101; S-7701; S-770108; RO-0220912 批准上市 Intermune 艾思瑞, Deskar, Etuary, Esbriet, Pirespa, Aisuryui United States 特发性肺纤维化 Genentech Inc 2008-10-16 皮肌炎, 放射性肺炎, 肾功能不全, 特发性肺纤维化, 系统性硬皮病, 间质性肺疾病, 肺纤维化, 糖尿病肾病, 尘肺 详情

LAP (TGF-beta 1)临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Nicousamide XLF-III-43 临床二期 中国医学科学院药物研究所 高血压肾病, 糖尿病肾病 详情
Disitertide P-144; NAFB-001; Peptide-144 临床二期 Digna Biotech, University Of Navarra 纤维化, 系统性硬皮病 详情
Vactosertib EW-7197; NOV-1301; TEW-7197 临床二期 Medpacto 实体瘤, 食道癌, 胃癌, 骨髓增生异常综合征, 移行细胞癌, 泌尿系肿瘤, 结直肠癌, 腺癌, 非小细胞肺癌 详情
Fluorofenidone AKF-PD 临床一期 达瑞医药香港有限公司, 海南海药股份有限公司, 中南大学 肝硬化, 肾脏纤维化 详情
YL-13027 YL-13027 临床一期 上海璎黎药业有限公司 实体瘤 详情
Yinfenidone Hydrochloride HEC-585; HEC-00000585 临床二期 宜昌东阳光药业股份有限公司 特发性肺纤维化 详情
盐酸美氟尼酮 临床一期 广州南鑫药业有限公司, 中南大学 糖尿病肾病 详情
DW-1029M DW-1029M 临床二期 韩国同和药业 糖尿病肾病 详情
STP-705 STP-705L; STP-705LU; STP-705LV; STP-705 临床二期 苏州圣诺生物医药技术有限公司, 美国圣诺制药公司 肝癌, 鲍温病, 基底细胞癌, 胆管上皮癌, 鳞状细胞癌, 瘢痕疙瘩, 皮肤增生性瘢痕, 肝细胞癌 详情
Bintrafusp alfa M-7824; GSK-4045154; MSB-0011359C 临床三期 默克雪兰诺 胆管癌, 实体瘤, 三阴性乳腺肿瘤, 胆管上皮癌, 胆囊癌, 宫颈癌, 非小细胞肺癌 详情

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