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> 【APRIL】
APRIL信息
英文名称：Tumor necrosis factor ligand superfamily member 13
中文名称：肿瘤坏死因子配体超家族成员13
靶点别称：Tumor Necrosis Factor Ligand 7B，CD256 Antigen，TNLG7B，CD256，TNF- and APOL-related leukocyte expressed ligand 2，TNFSF13，TNF-related death ligand 1，ZTNF2，TALL-2，APRIL，Tumor necrosis factor ligand superfamily member 13，TNF Superfamily Member 13，Tumor Necrosis Factor (Ligand) Superfamily， Member 13，TRDL-1，TALL2，Tumor Necrosis Factor Superfamily Member 13，Tumor Necrosis Factor-Like Protein ZTNF2，UNQ383/PRO715，A Proliferation-Inducing Ligand，Tumor Necrosis Factor-Related Death Ligand-1
中文名称：肿瘤坏死因子配体超家族成员13
靶点别称：Tumor Necrosis Factor Ligand 7B，CD256 Antigen，TNLG7B，CD256，TNF- and APOL-related leukocyte expressed ligand 2，TNFSF13，TNF-related death ligand 1，ZTNF2，TALL-2，APRIL，Tumor necrosis factor ligand superfamily member 13，TNF Superfamily Member 13，Tumor Necrosis Factor (Ligand) Superfamily， Member 13，TRDL-1，TALL2，Tumor Necrosis Factor Superfamily Member 13，Tumor Necrosis Factor-Like Protein ZTNF2，UNQ383/PRO715，A Proliferation-Inducing Ligand，Tumor Necrosis Factor-Related Death Ligand-1
上市药物数量：1
临床药物数量：8
最高研发阶段：批准上市
临床药物数量：8
最高研发阶段：批准上市
APRIL产品列表
属性
评论(2)
APL-H52D1|Human APRIL / TNFSF13 Protein, His,Flag Tag, active trimer (MALS verified)
- 188XXXXXXX5
- 采购该蛋白APL-H52D1，用于与TNFSF13的互作受体蛋白的ELISA检测，基于阳性对照抗体的阻断ELISA QC实验结果符合预期，可以用于筛选阻断型抗体。
- 2021-11-21
0人赞
APL-H52D1|Human APRIL / TNFSF13 Protein, His,Flag Tag, active trimer (MALS verified)
- 156XXXXXXX9
- 我们之前使用某公司的April试剂盒检测血清基质中April浓度，但由于试剂盒带的参比品问题，导致检测结果均低于定量下限，后采购ACRO公司的April蛋白作为标准品检测April，现在结果均非常理想，不同批次产品平行性好。
- 2021-08-18
1人赞
APRIL 分子别名
APRIL,TNFSF13,TALL-2,TRDL-1,CD256,TALL2,ZTNF2
APRIL 分子背景
APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies. The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities. In addition, expression of APRIL was regulated by miR-145 in GC cells.
APRIL 前沿进展
APRIL上市药物信息
| 英文名称 | 中文名称 | 研发代码 | 研发阶段 | 公司 | 最早商品名 | 最早批准国家 | 最早适应症 | 最早批准公司 | 最早批准日期 | 适应症 | 临床试验 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Telitacicept | 泰它西普 | RCT-18; RC-18; RCT18; RC18 | 批准上市 | 荣昌生物制药（烟台）股份有限公司 | 泰爱 | Mainland China | 系统性红斑狼疮 | RemeGen Co Ltd | 2021-03-09 | 重症肌无力, 复发-缓解型多发性硬化, 免疫球蛋白a肾病, 类风湿关节炎, Sjtoegren综合征, 多发性硬化, 系统性红斑狼疮, 视神经脊髓炎 | 详情 |
APRIL临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| RO-7297089 | RO-7297089; AFM-26; RG-6296 | 临床一期 | 基因泰克 | 多发性骨髓瘤 | 详情 |
| APRIL CAR-T Cell therapy (Yake Biotechnology) | 临床一期 | 上海雅科生物科技有限公司 | 多发性骨髓瘤 | 详情 | |
| Anti-BCMA CAR T-cell therapy (Huazhong University of Science and Technology) | 临床阶段不明 | 华中科技大学 | 多发性骨髓瘤 | 详情 | |
| Sibeprenlimab | VIS-649 | 临床二期 | 免疫球蛋白a肾病, 肾小球肾炎 | 详情 | |
| Atacicept | TACI-Ig | 临床三期 | Zymogenetics | 免疫球蛋白a肾病, 类风湿关节炎, 视神经炎, 多发性硬化, 狼疮肾炎, 多发性骨髓瘤, 系统性红斑狼疮, 非霍奇金淋巴瘤, 慢性淋巴细胞白血病 | 详情 |
| AUR-200 | AUR-200 | 临床一期 | Thunderbolt Pharma Inc | 自身免疫疾病 | 详情 |
| BION-1301 | BION-1301 | 临床二期 | Aduro Biotech | 免疫球蛋白a肾病, 多发性骨髓瘤 | 详情 |
| bb-21217 | bb-21217 | 临床一期 | 百时美施贵宝, Bluebird Bio | 多发性骨髓瘤 | 详情 |
| REGN-5458 | REGN-5458 | 临床二期 | Regeneron Pharmaceuticals Inc | 多发性骨髓瘤, 慢性肾功能不全 | 详情 |
