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APRIL信息

英文名称:Tumor necrosis factor ligand superfamily member 13
中文名称:肿瘤坏死因子配体超家族成员13
靶点别称:TNF- and APOL-related leukocyte expressed ligand 2,TNFSF13,TNF-related death ligand 1,ZTNF2,TALL-2,APRIL,Tumor necrosis factor ligand superfamily member 13,TNF Superfamily Member 13,Tumor Necrosis Factor (Ligand) Superfamily, Member 13,TRDL-1,TALL2,Tumor
上市药物数量:0
临床药物数量:7
最高研发阶段:批准上市

APRIL Molecule Synonym Name

APRIL,TNFSF13,TALL-2,TRDL-1,CD256,TALL2,ZTNF2

APRIL 分子背景

APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies. The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities. In addition, expression of APRIL was regulated by miR-145 in GC cells.

APRIL 参考文献

APRIL临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
BION-1301 BION-1301 临床二期 Aduro Biotech 免疫球蛋白a肾病, 多发性骨髓瘤 详情
VIS-649 VIS-649 临床二期 Visterra 免疫球蛋白a肾病, 肾小球肾炎 详情
Anti-BCMA CAR T-cell therapy (Huazhong University of Science and Technology) 临床阶段不明 华中科技大学 多发性骨髓瘤 详情
BCMAxCD3 bispecific antibody (Regeneron) REGN-5458 临床二期 Regeneron Pharmaceuticals Inc 多发性骨髓瘤 详情
APRIL CAR-T Cell therapy (Yake Biotechnology) 临床一期 Yake Biotechnology Ltd 多发性骨髓瘤 详情
Atacicept TACI-Ig 临床三期 Zymogenetics 免疫球蛋白a肾病, 类风湿关节炎, 狼疮肾炎, 多发性硬化, 多发性骨髓瘤, 视神经炎, 系统性红斑狼疮, 非霍奇金淋巴瘤, 慢性淋巴细胞白血病 详情
bb-21217 bb-21217 临床一期 Bluebird Bio 多发性骨髓瘤 详情

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