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CX3CL1信息

英文名称:C-X3-C motif chemokine ligand 1
中文名称:C-X3-C基序趋化因子配体1
靶点别称:Small Inducible Cytokine Subfamily D (Cys-X3-Cys), Member 1 (Fractalkine, Neurotactin),Small Inducible Cytokine Subfamily D (Cys-X3-Cys), Member-1,CX3CL1,Small-inducible cytokine D1,FKN,Fractalkine,A-152E5.2,C-X3-C Motif Chemokine Ligand 1,Chemokine (C-X3-C Motif) Ligand 1,CX3C Membrane-Anchored Chemokine,C-X3-C Motif Chemokine 1,Neurotactin,SCYD1,NTT,C3Xkine,ABCD-3,CXC3C,CXC3,NTN,Chemokine CX3CL1
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

CX3CL1 分子别名

CX3CL1,Fractalkine

CX3CL1 分子背景

Fractalkine is also known as C-X3-C motif chemokine 1 (CX3CL1) and neurotactin. Fractalkine is a large cytokine protein of 373 amino acids, it contains multiple domains and is the only known member of the CX3C chemokine family. Fractalkine is found commonly throughout the brain, particularly in neural cells, and its receptor is known to be present on microglial cells. It has also been found to be essential for microglial cell migration. CX3CL1 is also up-regulated in the hippocampus during a brief temporal window following spatial learning, the purpose of which may be to regulate glutamate-mediated neurotransmission tone. This indicates a possible role for the chemokine in the protective plasticity process of synaptic scaling.

CX3CL1 前沿进展

CX3CL1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Quetmolimab E-6011; KANAB-001 卫材株式会社 详情

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