Recombinant Proteins iso9001 ISO13485
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 > 【Integrin alpha L beta 2】重组蛋白信息

Integrin alpha L beta 2信息

英文名称:Integrin alpha-L/beta-2 (LFA-1)
中文名称:整合素α-L/β-2复合体(LFA-1)
靶点别称:Lymphocyte Function-Associated Antigen-1
上市药物数量:1
临床药物数量:0
最高研发阶段:批准上市

Integrin alpha L beta 2产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
IT2-H52W6
Human
Human Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein, His Tag&Tag Free
 
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Integrin alpha L beta 2 Molecule Synonym Name

Integrin alpha L beta 2,ITGAL&ITGB2

Integrin alpha L beta 2 分子背景

Integrin alpha-L beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha L beta 2 is also a receptor for F11R (By similarity). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin alpha L beta 2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.

Integrin alpha L beta 2 参考文献

Integrin alpha L beta 2上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Lifitegrast 利非司特 SHP-606; SPD-606; SAR-1118; SAR-1119 批准上市 Shire Development Llc Xiidra United States 干眼综合征 Novartis Pharma Ag 2016-07-11 干燥性角结膜炎, 干眼综合征, 变应性结膜炎 详情

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