BTNL9 分子别名
BTN3, BTNL9, VDLS1900, PRO4346, butyrophilin-like 9
BTNL9 分子背景
Butyrophilin (BTN) and butyrophilin-like (BTNL) proteins share significant homology and structural features with B7-molecules and like B7-molecules consist of regulatory molecules that modulate T-cell mediated immune responses. Butyrophilin-like 9 (BTNL9) is a member of the BTN/MOG Ig-superfamily and functions as a negative regulator of immune cell activation. Human BTNL9 is a 535 amino acid (aa) type I transmembrane glycoprotein that contains a 222 aa extracellular domain (ECD), a 21 aa helical transmembrane domain, and a 258 aa cytoplasmic domain.
BTNL9 前沿进展
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Lebrero-Fernández C., et al. 2016, Immun Inflamm Dis., 4(2), 191-200.
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Arnett HA., et al. 2014, Nat Rev Immunol., 14(8), 559-69.
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Abeler-Dörner L., et al. 2012, Trends Immunol., 33(1), 34-41.