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GDF-15信息

英文名称:Growth/differentiation factor 15
中文名称:生长分化因子-15
靶点别称:Placental TGF-beta,GDF-15,MIC1,PTGFB,MIC-1,PLAB,NSAID-activated gene 1 protein,Growth Differentiation Factor 15,Non-Steroidal Anti-Inflammatory Drug-Activated Gene-1,Placental Bone Morphogenetic Protein,NRG-1,PDF,Growth/Differentiation Factor 15,Macrophage Inhibitory Cytokine-1,PTGF-Beta,NSAID-regulated gene 1 protein,GDF15,Prostate Differentiation Factor,Macrophage Inhibitory Cytokine 1,NAG-1,NSAID (Nonsteroidal Anti-Inflammatory Drug)-Activated Protein 1
上市药物数量:0
临床药物数量:6
最高研发阶段:临床二期

GDF-15 分子别名

GDF15,GDF-15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB,NRG-1

GDF-15 分子背景

Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1). Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS). It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.

GDF-15 前沿进展

GDF-15临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
JNJ-9090 JNJ-9090 临床一期 强生 二型糖尿病, 肥胖症 详情
NN-9215 Human-GDF15; MIC-1; NN-9215; LA-GDF15 临床一期 诺和诺德制药 肥胖症 详情
GDF15 agonist (Lilly) 临床一期 礼来制药 糖尿病 详情
Visugromab CTL-002 CatalYm GmbH 详情
NGM-120 NGM-120 临床二期 Ngm Biopharmaceuticals 厌食, 恶病质 详情
AMG-171 AMG-171 安进 详情
AZD-8853 AZD-8853 临床二期 Astra Zeneca Gmbh 实体瘤, 膀胱癌, 结直肠癌, 非小细胞肺癌 详情

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