CTGF 靶点蛋白|抗体药物|临床药物信息

CTGF信息

英文名称：Connective tissue growth factor
中文名称：结缔组织生长因子
靶点别称：Cellular communication network factor 2，IBP-8，Hypertrophic chondrocyte-specific protein 24，IGF-binding protein 8，IGFBP-8，Connective tissue growth factor，IGFBP8，CCN2，Insulin-like growth factor-binding protein 8，HCS24，CCN family member 2，CTGF，NOV2

上市药物数量：1
临床药物数量：5
最高研发阶段：批准上市

CTGF产品列表

筛选结果

产品库

在线 (5)

物种

标签

属性

Protein (5)

标记

货号	物种	产品描述
CTF-H52H5	Human	Human CTGF / CCN2 Protein, His Tag
CTF-H82E6	Human	Biotinylated Human CTGF / CCN2 Protein, His,Avitag™ (recommended for biopanning)
CTF-M52Hc	Mouse	Mouse CTGF / CCN2 Protein, His Tag
GTF-H5253	Human	Human CTGF / CCN2 Protein, Fc Tag
GTF-R52H4	Rhesus macaque	Rhesus macaque CTGF / CCN2 Protein, His Tag

CTF-H52H5|Human CTGF / CCN2 Protein, His Tag

150XXXXXXX0

3人赞

我们买这个蛋白是用来做结合活性检测的，实验还是获得了一个很漂亮的S行曲线，和我们的产品结合效果非常好，后续使用中考察了一下，发现该蛋白稳定性好，批间一致性也好，能满足我们的要求，总体使用效果好。
2021-08-25

CTF-M52Hc|Mouse CTGF / CCN2 Protein, His Tag

136XXXXXXX0

3人赞

这是个靶点蛋白，通过ELISA方法筛选人猴鼠不同种属cross binding的阳性抗体，进行后续功能试验的验证。
2021-08-13

GTF-R52H4|Rhesus macaque CTGF / CCN2 Protein, His Tag

139XXXXXXX9

1人赞

用于杂交瘤筛选，期望拿到好亲和力的抗体，通过和BMK的结合曲线发现亲和力很好，包被用量很低的情况下也能有很大的窗口。
2021-09-26

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CTGF分子别名

CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8

CTGF分子背景

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

CTGF上市药物信息

英文名称	中文名称	研发代码	研发阶段	公司	最早商品名	最早批准国家	最早适应症	最早批准公司	最早批准日期	适应症	临床试验
Penicillamine	青霉胺		批准上市	Valeant	Distamine, Pemine, Trisorcin, Cuprimine, Cupramine, Trolovol	Mainland China	威尔逊氏病, 铅中毒, 类风湿关节炎, 重金属中毒	Sichuan Pharmaceutical Co Ltd	1970-12-04	重金属中毒, 类风湿关节炎, 威尔逊氏病, 胱氨酸尿症, 铅中毒	详情

CTGF临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
PRS-220	PRS-220	临床一期	Pieris Pharmaceuticals	特发性肺纤维化	详情
SHR-1906	SHR-1906	临床一期	广东恒瑞医药有限公司	特发性肺纤维化	详情
Pamrevlumab	FG-3019	临床三期	Fibrogen Inc	二型糖尿病, 特发性肺纤维化, 胰腺癌, 新型冠状病毒肺炎, 肝硬化, 局灶性节段性肾小球硬化症, 杜氏肌营养不良症, 糖尿病肾病, 糖尿病	详情
LEM-S401	LEM-S401; LEMS401	临床一期	Lemonex Inc	瘢痕	详情
OLX-10010	cp-asiCTGF; OLX-101A; OLX-10010; BMT-101; OLX-101	临床二期	Olix Pharmaceuticals Inc	肺纤维化, 湿性黄斑变性, 年龄相关性黄斑变性, 皮肤增生性瘢痕	详情

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CTGF