Recombinant Proteins iso9001 ISO13485
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CTGF信息

英文名称:Connective tissue growth factor
中文名称:结缔组织生长因子
靶点别称:Cellular communication network factor 2,IBP-8,Hypertrophic chondrocyte-specific protein 24,IGF-binding protein 8,IGFBP-8,Connective tissue growth factor,IGFBP8,CCN2,Insulin-like growth factor-binding protein 8,HCS24,CCN family member 2,CTGF,NOV2
上市药物数量:2
临床药物数量:4
最高研发阶段:批准上市

CTGF Molecule Synonym Name

CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8

CTGF 分子背景

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

CTGF 参考文献

CTGF上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Netarsudil Dimesylate AR-13224; AR-13324 批准上市 Aerie Pharmaceuticals Rhopressa EU 高眼压, 开角型青光眼 Aerie Pharmaceuticals Ireland Ltd 2017-12-18 开角型青光眼, 高眼压, 青光眼, 角膜水肿, Fuchs角膜内皮营养不良 详情
Penicillamine 青霉胺 批准上市 Valeant Distamine, Pemine, Trisorcin, Cuprimine, Cupramine, Trolovol Mainland China 重金属中毒, 类风湿关节炎, 威尔逊氏病, 铅中毒 Sichuan Pharmaceutical Co Ltd 1970-12-04 重金属中毒, 类风湿关节炎, 威尔逊氏病, 胱氨酸尿症, 铅中毒 详情
Netarsudil mesylate/Latanoprost PG-324 批准上市 Aerie Pharmaceuticals Inc Rocklatan, Roclanda EU 开角型青光眼, 高眼压 Aerie Pharmaceuticals Ireland Ltd 2019-03-12 开角型青光眼, 高眼压 详情

CTGF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Setogepram PBI-4050 临床三期 Prometic Life Sciences 囊性纤维化, 二型糖尿病, 特发性肺纤维化, X综合征, Alstrom综合征, 糖尿病 详情
OLX-10010 BMT-101; OLX-101; OLX-10010; cp-asiCTGF; OLX-101A 临床二期 Olix Pharmaceuticals 肺纤维化, 湿性黄斑变性, 皮肤增生性瘢痕, 年龄相关性黄斑变性 详情
RXI-109 RXI-109 临床二期 Rxi Pharmaceutical 粪类圆线虫病, 瘢痕, 瘢痕疙瘩, 年龄相关性黄斑变性, 皮肤增生性瘢痕 详情
Pamrevlumab FG-3019 临床三期 Fibrogen 二型糖尿病, 特发性肺纤维化, 胰腺癌, 肝硬化, 新型冠状病毒肺炎, 局灶性节段性肾小球硬化症, 杜氏肌营养不良症, 糖尿病肾病, 糖尿病 详情

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