SIRP beta Molecule Synonym Name
CD172b antigen,CD172b,DKFZp686A05192,FLJ26614,SIRP beta 1,SIRPB1,SIRP-BETA-1,9930027N05Rik,SIRP-beta
SIRP beta 分子背景
Signal-regulatory protein beta-1 (SIRP beta 1) also known as SIRPβ1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. SIRPβ1 is a transmembrane protein that has three Ig-like domains in its extracellular region and a short cytoplasmic tail. Human SIRPβ1 is expressed on monocytes and granulocytes but not on lymphocytes. SIRP beta 1 contains short cytoplasmic domains that lack cytoplasmic sequence motifs capable of recruiting SHP-2 and SHP-1. In addition, they contain a single basic lysine residue within the hydrophobic transmembrane domain.
SIRP beta 参考文献
Gaikwad S., et al. 2009, Am J Pathol., 175(6), 2528-39.
Dietrich J., et al. 2000, J Immunol., 164(1), 9-12.
Tomasello E., et al. 2000, Eur J Immunol., 30(8), 2147-56.