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GP120信息

英文名称:HIV envelope protein gp120
中文名称:HIV包膜蛋白gp120
靶点别称:HIV Envelope Protein gp120
上市药物数量:2
临床药物数量:6
最高研发阶段:批准上市

GP120产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
GP4-V15227
HIV-1 (CN54)
HIV-1 [HIV-1/Clade B/C (CN54)] GP120 Protein, His Tag
GP0-V182E6
HIV-1 (CN54)
Biotinylated HIV-1 [HIV-1/Clade B/C (CN54)] GP120 Protein, His,Avitag
 
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GP120 Molecule Synonym Name

GP120,GP120-CN54

GP120 分子背景

Human Immunodeficiency Virus (HIV) can be divided into two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa. HIV-2 is related to viruses found in sooty mangabeys. HIV-1 viruses may be further divided into groups. The HIV-1 group M viruses predominate and are responsible for the AIDS pandemic. Some of the HIV-1 group M subtypes are known to be more virulent or are resistant to different medications. HIV-2 viruses are thought to be less virulent and transmissible than HIV-1 M group viruses. Envelope glycoprotein GP120 (or gp120) is the name of the glycoprotein which forms the spikes sticking out of a HIV virus particle. gp120 is essential for virus entry into cells as it plays a vital role in seeking out specific cell surface receptors for entry. Three gp120s, bound as heterodimers to a transmembrane glycoprotein, gp41, are thought to combine in a trimer to form the envelope spike, which is involved in virus-cell attachment. One half of the molecular weight of gp120 is due to the carbohydrate side chains (the "glyco-" in "glycoprotein"). These are sugar residues which form something almost like a sugar "dome" over the gp120 spikes. This dome prevents gp120 from being recognised by the human immune response. As the HIV virus and the human CD4 cell come together, the gp120 binding site "snaps open" at the last minute.The glycoprotein gp120 is anchored to the viral membrane, or envelope, via non-covalent bonds with the transmembrane glycoprotein, gp41. It is involved in entry into cells by binding to CD4 receptors, particularly helper T-cells. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds.

GP120 参考文献

GP120上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Radha-108 批准上市 Biomix Network Receptol HIV感染 详情
Fostemsavir Tromethamine GSK 3684934; BMS 626529 prodrug; BMS-663068; 97IQ273H4L (UNII code) 批准上市 百时美施贵宝 Rukobia EU HIV感染 Viiv Healthcare Bv 2020-07-02 HIV感染 详情

GP120临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Microbicide monoclonal antibody triple combination (Polymun Scientific Immunobiologische Forschung) 临床一期 Polymun Scientific HIV感染 详情
Elipovimab GS-9722 临床一期 吉利德 HIV感染 详情
KD-247 KD-247 临床一期 Kaketsuken HIV感染 详情
10-1074 10-1074; 10-1074-LS 临床二期 The Rockefeller University HIV感染 详情
PDPHV-201401 PDPHV-201401 临床一期 National Institute Of Allergy And Infectious Diseases (Niaid) HIV感染 详情
3BNC-117 3BNC117-LS; 3BNC117 临床二期 The Rockefeller University HIV感染, 获得性免疫缺损综合征 详情

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