Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, also known as CD150, is the prototypic member of the SLAM subfamily of the CD2 protein family.SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. The type I transmembrane glycoprotein Signaling Lymphocytic Activation Molecule (SLAM).
Cannons JLt, et al., 2011, Annu Rev Immunol., 29, 665-705.
Jordan MA, et al., 2011, J Immunol., 186(7), 3953-65.
Berger SB, et al., 2010, Nat Immunol., 11(10), 920-7.