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 > 【Prolactin R】重组蛋白信息

Prolactin R信息

英文名称:Prolactin receptor
中文名称:催乳素受体
靶点别称:PRL-R,PRLR,Prolactin Receptor,Secreted Prolactin Binding Protein,HPRL Receptor,RI-PRLR,HPRLrI,HPRL,MFAB,Receptors, Prolactin
上市药物数量:0
临床药物数量:2
最高研发阶段:临床一期

Prolactin R产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
PRP-H5251
Human
Human Prolactin R / PRLR Protein, Fc Tag
PRR-H52Ha
Human
Human Prolactin R / PRLR Protein, His Tag
 
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Prolactin R 分子别名

Prolactin R, PRLR, PRL-R

Prolactin R 分子背景

As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.

Prolactin R 参考文献

Prolactin R临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Rolinsatamab talirine h16f; ABBV-176; DC-1630993 临床一期 艾伯维 肿瘤 详情
BAY-1158061 BAY-1158061 临床一期 拜耳 子宫内膜异位症 详情

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