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 > 【Integrin alpha E beta 7】

Integrin alpha E beta 7信息

英文名称:Integrin alpha-E/beta-7
中文名称:整合素αEβ7
靶点别称
上市药物数量:0
临床药物数量:1
最高研发阶段:临床三期

Integrin alpha E beta 7产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
IT7-H52W7
Human
Human Integrin alpha E beta 7 (ITGAE&ITGB7) Heterodimer Protein, His Tag&Tag Free
ACRO质量管理体系
 
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Integrin alpha E beta 7 分子别名

Integrin alpha E beta 7,ITGAE&ITGB7,HML-1,CD103,ITGAE&B7

Integrin alpha E beta 7 分子背景

Integrin alpha E beta 7 consist of two major subunits: Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) and Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. Integrin alpha E beta 7 (CD103) is expressed mainly by cells of the T lymphocyte lineage within mucosal tissues. This is a strikingly narrow pattern of expression compared with that of other integrins. Lymphocytes expressing alpha E beta 7 are abundant in the gut and comprise a major part of the total T cell complement of the body. The effectiveness of lung transplantation is marred by the relatively high incidence of rejection. The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integrin, alpha(E)(CD103)beta(7). This integrin is not a homing receptor, but is thought to retain lymphocytes at the epithelial surface.

Integrin alpha E beta 7 前沿进展

Integrin alpha E beta 7临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Etrolizumab PRO-145223; rhuMAb-Beta7; R-7413; RG-7413 临床三期 基因泰克 溃疡性结肠炎, 克罗恩病 详情

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