Integrin alpha E beta 7 靶点蛋白|抗体药物|临床药物信息

Integrin alpha E beta 7信息

英文名称：Integrin alpha-E/beta-7
中文名称：整合素αEβ7
靶点别称：

上市药物数量：0
临床药物数量：1
最高研发阶段：临床三期

Integrin alpha E beta 7产品列表

筛选结果

产品库

在线 (1)

物种

Human (1)

标签

His Tag (1)

属性

Protein (1)

标记

Unconjugated (1)

货号	物种	产品描述	蛋白结构	纯度	活性
IT7-H52W7	Human	Human Integrin alpha E beta 7 (ITGAE&ITGB7) Heterodimer Protein, His Tag&Tag Free

Integrin alpha E beta 7 分子别名

Integrin alpha E beta 7,ITGAE&ITGB7,HML-1,CD103,ITGAE&B7

Integrin alpha E beta 7 分子背景

Integrin alpha E beta 7 consist of two major subunits: Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) and Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. Integrin alpha E beta 7 (CD103) is expressed mainly by cells of the T lymphocyte lineage within mucosal tissues. This is a strikingly narrow pattern of expression compared with that of other integrins. Lymphocytes expressing alpha E beta 7 are abundant in the gut and comprise a major part of the total T cell complement of the body. The effectiveness of lung transplantation is marred by the relatively high incidence of rejection. The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integrin, alpha(E)(CD103)beta(7). This integrin is not a homing receptor, but is thought to retain lymphocytes at the epithelial surface.

Integrin alpha E beta 7 前沿进展

Integrin alpha E beta 7临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Etrolizumab	PRO-145223; rhuMAb-Beta7; R-7413; RG-7413	临床三期	基因泰克	溃疡性结肠炎, 克罗恩病	详情

会议日历

会议一览

Integrin alpha E beta 7