Integrin alpha E beta 7 分子别名
Integrin alpha E beta 7,ITGAE&ITGB7,HML-1,CD103,ITGAE&B7
Integrin alpha E beta 7 分子背景
Integrin alpha E beta 7 consist of two major subunits: Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) and Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. Integrin alpha E beta 7 (CD103) is expressed mainly by cells of the T lymphocyte lineage within mucosal tissues. This is a strikingly narrow pattern of expression compared with that of other integrins. Lymphocytes expressing alpha E beta 7 are abundant in the gut and comprise a major part of the total T cell complement of the body.
The effectiveness of lung transplantation is marred by the relatively high incidence of rejection. The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integrin, alpha(E)(CD103)beta(7). This integrin is not a homing receptor, but is thought to retain lymphocytes at the epithelial surface.
Integrin alpha E beta 7 前沿进展
- Smyth, L., et al., 2007, Clinical and Experimental Immunology., 149(1), 162–170.
- Floc’h, A. L.., et al., 2007, Journal of Experimental Medicine., 204(3), 559–570.
- (3) Manicone, A. M., et al., 2009, The American Journal of Pathology., 175(6), 2319–2331.