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Integrin alpha E beta 7信息
英文名称：Integrin alpha-E/beta-7
中文名称：整合素αEβ7
靶点别称：
中文名称：整合素αEβ7
靶点别称：
上市药物数量：0
临床药物数量：1
最高研发阶段：临床三期
临床药物数量：1
最高研发阶段：临床三期
Integrin alpha E beta 7产品列表
| 货号 | 物种 | 产品描述 | 蛋白结构 | 纯度 | 活性 |
|---|---|---|---|---|---|
| IT7-H52W7 |
 Human |
Human Integrin alpha E beta 7 (ITGAE&ITGB7) Heterodimer Protein, His Tag&Tag Free (SPR verified) |
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Integrin alpha E beta 7 分子别名
Integrin alpha E beta 7,ITGAE&ITGB7,HML-1,CD103,ITGAE&B7
Integrin alpha E beta 7 分子背景
Integrin alpha E beta 7 consist of two major subunits: Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) and Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. Integrin alpha E beta 7 (CD103) is expressed mainly by cells of the T lymphocyte lineage within mucosal tissues. This is a strikingly narrow pattern of expression compared with that of other integrins. Lymphocytes expressing alpha E beta 7 are abundant in the gut and comprise a major part of the total T cell complement of the body.
The effectiveness of lung transplantation is marred by the relatively high incidence of rejection. The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integrin, alpha(E)(CD103)beta(7). This integrin is not a homing receptor, but is thought to retain lymphocytes at the epithelial surface.
Integrin alpha E beta 7 前沿进展
Integrin alpha E beta 7临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| Etrolizumab | R-7413; RG-7413; PRO-145223; rhuMAb-Beta7 | 临床三期 | 基因泰克 | 炎症性肠疾病, 溃疡性结肠炎, 克罗恩病 | 详情 |
