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 > 【CBLB】

CBLB信息

英文名称:E3 ubiquitin-protein ligase CBL-B
中文名称:E3泛素连接酶CBL-B
靶点别称:Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B,Casitas B-lineage lymphoma proto-oncogene b,RING-type E3 ubiquitin transferase CBL-B,SH3-binding protein CBL-B,RING finger protein 56,Nbla00127,RNF56,Signal transduction protein CBL-B,Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B,Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase B,Cbl Proto-Oncogene B,Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase,Cbl-B
上市药物数量:0
临床药物数量:1
最高研发阶段:临床前

CBLB产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CBB-H5148
Human
Human CBLB / RNF56 Protein, His Tag
 
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CBLB 分子别名

CBL-B,CBLB,RNF56

CBLB 分子背景

Casitas B-lineage lymphoma proto-oncogene b (CBLB) is also known as RNF56. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle.

CBLB 前沿进展

CBLB临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
DeTIL-0255 DeTIL-0255; NX-0255; NX-DeTIL-0255-201 Nurix Therapeutics Inc 详情
APN-401 APN-401 Apeiron Biologics 详情

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