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IL-21信息

英文名称:Interleukin-21
中文名称:白细胞介素-21
靶点别称:Za11,IL-21,CVID11,Interleukin-21 Isoform,Interleukin 21
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

IL-21产品列表

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IL-21 分子别名

IL21,Za11,Interleukin-21

IL-21 分子背景

Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

IL-21 前沿进展

IL-21临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
IL-21 mab (Lilly) 临床一期 礼来制药 免疫紊乱 详情
Avizakimab BOS-161721 临床二期 Medimmune, Boston Pharmaceuticals 系统性红斑狼疮 详情

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