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IL-21信息

英文名称:Interleukin-21
中文名称:白细胞介素-21
靶点别称:Za11,IL-21,CVID11,Interleukin-21 Isoform,Interleukin 21
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

IL-21产品列表

ACRO质量管理体系
 
评论(2)
IL1-H82F7|Biotinylated Human IL-21 Protein, Fc,Avitag™, premium grade
  1. 188XXXXXXX2
  2. 0人赞
  3. 产品的活性SEC检测结果与产品的介绍相符,用于SPR检测时的对照品,用于检测样品的检测,能很好的将检测样品的结合力进行检测,另外产品的稳定性也比较高。
  4. >
  5. 2023-06-21
IL1-M52H3|Mouse IL-21 Protein, His Tag
  1. 186XXXXXXX2
  2. 0人赞
  3. 发货快,质量可靠,产品稳定性好,数据稳定,已经多次用于实验,长期多次回购。性价比好,最主要是发货真的很快,货期短,优势明显!
  4. 2023-07-26
 

IL-21分子别名

IL21,Za11,Interleukin-21

IL-21分子背景

Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

IL-21临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
hV-01 hV-01 临床一期 杭州康万达医药科技有限公司 实体瘤 详情
NN-9828 NN-8828; NN-9828; Anti-IL21; NNC114-0005; NNC0114-0006; NNC-0114-0000-0005 临床二期 百时美施贵宝 一型糖尿病, 类风湿关节炎, 系统性红斑狼疮, 炎性疾病, 糖尿病, 克罗恩病 详情
Avizakimab BOS-161721 临床二期 Medimmune, Boston Pharmaceuticals Inc 系统性红斑狼疮 详情
IL-21 mab (Lilly) 临床一期 礼来制药 免疫紊乱 详情

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