Interleukin-21 (IL-21) is a pleiotropic cytokine with actions on a broad range of lymphoid, myeloid and epithelial cells. IL-21 induces a functional programme in CD8+ T cells that leads to enhanced survival, antiviral activity and antitumour activity. IL-21 has a key role in the development of T helper 17 (TH17) cells, which contribute to pathogenesis in a range of inflammatory diseases.
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