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LILRA4信息

英文名称:Leukocyte immunoglobulin-like receptor subfamily A member 4
中文名称:人白细胞免疫球蛋白样受体亚家族A成员4
靶点别称
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

LILRA4产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
LI4-H5243
Human
Human LILRA4 / CD85g / ILT7 Protein, His Tag (MALS verified)
 
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LILRA4 分子别名

LILRA4,CD85g,ILT7,ILT-7

LILRA4 分子背景

Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4/ILT7/CD85g) is a marker of plasmacytoid dendritic cells (pDCs), which are reported to be a major source of the abnormally high levels of IFNα associated with autoimmune diseases. Targeting LILRA4 with therapeutic antibodies to promote killing of these IFNα-producing pDCs is being investigated as a novel approach to alleviating the symptoms of autoimmune diseases. LILRA4 is an immunoglobulin-like protein preferentially expressed on the surface of human plasmacytoid dendritic cells (pDCs). It interacts with bone marrow stromal cell antigen 2 to control the Toll-like receptor (TLR) driven response by pDCs to viral infection. It may also be involved in modulating pDC-tumour interactions. pDCs are a source of the excess IFNα which drives autoimmune disease symptoms.

LILRA4 前沿进展

LILRA4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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