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 > 【LRRC32】重组蛋白信息

LRRC32信息

英文名称:Transforming growth factor beta activator LRRC32
中文名称:糖蛋白A主导重复序列
靶点别称:Glycoprotein A Repetitions Predominant,D11S833E,Garpin,LRRC32,Leucine-Rich Repeat-Containing Protein 32,Transforming Growth Factor Beta Activator LRRC32,Leucine Rich Repeat Containing 32,GARP
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

LRRC32产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
LR2-H5256
Human
Human LRRC32 / GARP / Garpin / D11S833E Protein, Fc Tag
 
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LRRC32 分子别名

GARP,Garpin,D11S833E

LRRC32 分子背景

Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.

LRRC32 参考文献

LRRC32临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
ABBV-151 MGH-8; ABBV151; AGRX-115; ARGX-115 临床一期 Argen-X 肿瘤 详情

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