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> 【LRRC32】
LRRC32信息
英文名称：Transforming growth factor beta activator LRRC32
中文名称：糖蛋白A主导重复序列
靶点别称：Leucine Rich Repeat Containing 32，D11S833E，Garpin，Leucine-Rich Repeat-Containing Protein 32，LRRC32，Transforming Growth Factor Beta Activator LRRC32，GARP，Glycoprotein A Repetitions Predominant
中文名称：糖蛋白A主导重复序列
靶点别称：Leucine Rich Repeat Containing 32，D11S833E，Garpin，Leucine-Rich Repeat-Containing Protein 32，LRRC32，Transforming Growth Factor Beta Activator LRRC32，GARP，Glycoprotein A Repetitions Predominant
上市药物数量：0
临床药物数量：2
最高研发阶段：临床一期
临床药物数量：2
最高研发阶段：临床一期
LRRC32产品列表
| 货号 | 物种 | 产品描述 | 蛋白结构 | 纯度 | 活性 |
|---|---|---|---|---|---|
| LR2-H5256 |
 Human |
Human LRRC32 / GARP / Garpin / D11S833E Protein, Fc Tag |
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LRRC32 分子别名
GARP,Garpin,D11S833E
LRRC32 分子背景
Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.
