LRRC32 靶点蛋白|抗体药物|临床药物信息

LRRC32信息

英文名称：Transforming growth factor beta activator LRRC32
中文名称：糖蛋白A主导重复序列
靶点别称：Glycoprotein A Repetitions Predominant，D11S833E，Garpin，LRRC32，Leucine-Rich Repeat-Containing Protein 32，Transforming Growth Factor Beta Activator LRRC32，Leucine Rich Repeat Containing 32，GARP

上市药物数量：0
临床药物数量：1
最高研发阶段：临床一期

LRRC32产品列表

筛选结果

产品库

在线 (1)

物种

Human (1)

标签

Fc Tag (1)

属性

Protein (1)

标记

Unconjugated (1)

货号	物种	产品描述	蛋白结构	纯度	活性
LR2-H5256	Human	Human LRRC32 / GARP / Garpin / D11S833E Protein, Fc Tag

LRRC32 分子别名

GARP,Garpin,D11S833E

LRRC32 分子背景

Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.

LRRC32 参考文献

LRRC32临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
ABBV-151	MGH-8; ABBV151; AGRX-115; ARGX-115	临床一期	Argen-X	肿瘤	详情

会议日历

会议一览

LRRC32 重组蛋白