Integrin alpha 6 beta 1 Molecule Synonym Name
Integrin alpha 6 beta 1,ITGA6&ITGB1
Integrin alpha 6 beta 1 分子背景
Integrin alpha 6 beta 1, also called platelet glycoprotein GPIc-IIa, is a receptor for laminin on platelets. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. ITGA6 has been shown to interact with TSPAN4 and GIPC1.
Integrin alpha 6 beta 1 参考文献
Tachibana I, et al., 1997, The Journal of Biological Chemistry, 272 (46): 29181-29189.
Tani TT, et al., 2001, The Journal of Biological Chemistry, 276 (39): 36535-36542.
Lipscomb EA, etal., 2005, Cancer Metastasis Reviews, 24 (3): 413-423.