M-CSF 分子别名
M-CSF,CSF-1,Lanimostim
M-CSF 分子背景
The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which influences hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 receptor. Macrophage colony-stimulating factor has been shown to interact with PIK3R2. M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. Locally produced M-CSF in the vessel wall contributes to the development and progression of atherosclerosis.
M-CSF 前沿进展
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Sapi E., 2004, Exp. Biol. Med., 229 (1): 1-11.
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Jang Mei-Huei, 2006, The Journal of Immunology, 177 (6): 4055-4063.
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Cao, Qi, 2014, Kidney International, 85 (4): 794-806.