登录 | 注册    关注公众号  
微信公众号
搜索

IL-13信息

英文名称:Interleukin-13
中文名称:白细胞介素-13
靶点别称:Interleukin-13,IL13,Interleukin 13,IL-13,Bronchial Hyperresponsiveness-1 (Bronchial Asthma),Allergic Rhinitis,P600,NC30,MGC116789,MGC116788,BHR1,MGC116786,ALRH
上市药物数量:1
临床药物数量:5
最高研发阶段:批准上市

IL-13 分子别名

IL13,ALRH,BHR1,MGC116786,MGC116788,MGC116789,P600,Interleukin-13

IL-13 分子背景

Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

IL-13 前沿进展

IL-13上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Tralokinumab BAK-502G9; CAT-354 批准上市 Medimmune Llc Adtralza, ADBRY United States 特应性皮炎 Leo Pharma A/S 2021-06-17 特发性肺纤维化, 哮喘, 溃疡性结肠炎, 特应性皮炎 详情

IL-13临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Dectrekumab/VAK-694 QBX-258 临床二期 诺华制药 淋巴水肿, 哮喘 详情
SAR-443726 SAR-443726 临床一期 赛诺菲 特应性皮炎 详情
SAR-443765 SAR-443765 临床一期 赛诺菲 炎性疾病 详情
AIR-645 AIR-645; ISIS-369645 Ionis Pharmaceuticals Inc 详情
Romilkimab SUB-33159; SAR-156597 赛诺菲 详情
GSK-2434735 GSK-2434735 葛兰素史克 详情
Lebrikizumab RG-3637; TNX-650; Anti-IL-13; MILR-1444A; PRO-301444; RO-4909832; RO-5490255; DRM-06; R-3637 临床三期 基因泰克 阿尔茨海默病 详情
Abrezekimab CDP-7766; VR-942; UCB-4144 Vectura, 比利时优时比制药有限公司 详情
Berdazimer sodium NVN1000-SB206; MAP3-NONOate - SB-206; SB-019; NVN-1000-SB-206-Novan; SB-206 Novan 详情
AMG-317 AMG-317 安进 详情
RG-1671 R-1671; RG-1671 罗氏 详情
RO-7040547 RG-7990; BIT-7201A; RO-7040547 基因泰克, Novimmune Sa 详情
Cendakimab ABT-308; RPC-4046; CC-93538 临床三期 Abbott Laoratories 嗜酸细胞性胃肠炎(EG), 嗜酸性粒细胞性食管炎, 哮喘, 特应性皮炎, 湿疹 详情

消息提示

请输入您的联系方式,再点击提交!

确定