IL-13 靶点蛋白|抗体药物|临床药物信息

IL-13信息

英文名称：Interleukin-13
中文名称：白细胞介素-13
靶点别称：Interleukin-13，IL13，Interleukin 13，IL-13，Bronchial Hyperresponsiveness-1 (Bronchial Asthma)，Allergic Rhinitis，P600，NC30，MGC116789，MGC116788，BHR1，MGC116786，ALRH

上市药物数量：1
临床药物数量：6
最高研发阶段：批准上市

IL-13产品列表

筛选结果

产品库

在线 (7)

物种

标签

属性

Protein (7)

标记

货号	物种	产品描述
IL3-C5249	Cynomolgus	Cynomolgus IL-13 Protein, His Tag (MALS verified)
IL3-C52H4	Canine	Canine IL-13 Protein, His Tag
IL3-H5256	Human	Human IL-13 Protein, Fc Tag
IL3-H52G3	Human	Human IL-13 Protein, GST Tag
IL3-H52H4	Human	Human IL-13 Protein, His Tag
IL3-H82E5	Human	Biotinylated Human IL-13 Protein, His,Avitag™
IL3-M5249	Mouse	Mouse IL-13 Protein, His Tag

IL3-H52H4|Human IL-13 Protein, His Tag

156XXXXXXX1

1人赞

2月份购买了IL-3蛋白产品做开发实验的试用，本产品的表现超出预期，抗原和目标样品结合非常稳定，耐用性数据也非常漂亮，几轮实验后很快就拟定了实验参数，省时省力！后续会持续支持ACRO的产品
2023-03-15

IL3-C52H4|Canine IL-13 Protein, His Tag

138XXXXXXX9

1人赞

我们购买该产品用于做抗体筛选，用作检测试剂，可应用于Binding ELISA和细胞学实验，产品生物学活性好，并且特异性很高。
2022-11-23

IL3-H52H4|Human IL-13 Protein, His Tag

151XXXXXXX9

0人赞

Human IL-13 Protein, His Tag(货号IL3-H52H4)，我们用来做Binding ELISA的，评价自主研发的ADC药物与IL3靶点的一个结合能力，结果显示，曲线图谱表达还不错，同时该抗原的表现也比较特异，果然Acro家的抗体一如既往好用
2023-02-13

IL-13分子别名

IL13,ALRH,BHR1,MGC116786,MGC116788,MGC116789,P600,Interleukin-13

IL-13分子背景

Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

IL-13上市药物信息

英文名称	中文名称	研发代码	研发阶段	公司	最早商品名	最早批准国家	最早适应症	最早批准公司	最早批准日期	适应症	临床试验
Tralokinumab		BAK-502G9; CAT-354	批准上市	Medimmune Llc	ADBRY, Adtralza	EU	特应性皮炎	Leo Pharma Inc	2021-06-17	特发性肺纤维化, 哮喘, 溃疡性结肠炎, 特应性皮炎	详情

IL-13临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Lebrikizumab	RG-3637; TNX-650; Anti-IL-13; MILR-1444A; PRO-301444; RO-4909832; RO-5490255; DRM-06; R-3637	临床三期	基因泰克	特发性肺纤维化, 霍奇金病, 皮炎, 皮肤性疾病, 哮喘, 阿尔茨海默病, 慢性阻塞性肺疾病, 特应性皮炎, 湿疹, 遗传性皮肤病	详情
SAR-443726	SAR-443726	临床一期	赛诺菲	特应性皮炎	详情
Dectrekumab/VAK-694	QBX-258	临床二期	诺华制药	淋巴水肿, 哮喘	详情
SAR-443765	SAR-443765	临床一期	赛诺菲	哮喘, 炎性疾病	详情
PF-07264660	PF-07264660	临床一期	辉瑞		详情
Cendakimab	RPC-4046; ABT-308; CC-93538	临床三期	Abbott Laboratories	嗜酸细胞性胃肠炎（EG）, 嗜酸性粒细胞性食管炎, 哮喘, 特应性皮炎, 湿疹	详情

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IL-13