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SCF-M5228|Mouse SCF / KITLG Protein, His Tag
  1. 153XXXXXXX5
  2. 1人赞
  3. 使用该产品Mouse SCF / KITLG Protein, His Tag(SCF-M5228-50ug包装),主要出于研究细胞活性实验的目的,应用于诱导人骨髓细胞分化实验,获得了满意的结果,通过诱导4-8周的时间可以得到分化的目的细胞。
  4. 2022-05-21
 

SCF 分子别名

KITLG,FPH2,KL-1,Kitl,MGF,SCF,SF,SHEP7,KL

SCF 分子背景

Stem Cell Factor is also known as SCF, kit-ligand, KL, steel factor, KITLG, FPH2, KL-1, Kitl, MGF, SCF, SF, or SHEP7, and is a cytokine that binds to the c-Kit receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis. The soluble and transmembrane forms of the protein are formed by alternative splicing of the same RNA transcript.Soluble and transmembrane SCF is produced by fibroblasts and endothelial cells. Soluble SCF has a molecular weight of 18,5 KDa and forms a dimer. SCF plays an important role in the hematopoiesis during embryonic development. Sites where hematopoiesis takes place, such as the fetal liver and bone marrow, all express SCF. During development, the presence of the SCF also plays an important role in the localization of melanocytes, cells that produce melanin and control pigmentation. SCF plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. SCF may be used along with other cytokines to culture HSCs and hematopoietic progenitors. The expansion of these cells ex-vivo (outside the body) would allow advances in bone-marrow transplantation, in which HSCs are transferred to a patient to re-establish blood formation.

SCF 前沿进展

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