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BAFFR信息

英文名称:B-cell activating factor receptor
中文名称:B细胞活化因子受体
靶点别称:BAFFR,B Cell-Activating Factor Receptor,Prolixin,BROMIX,CD268,Tumor Necrosis Factor Receptor Superfamily, Member 13C,Tumor Necrosis Factor Receptor Superfamily Member 13C,BR3,CVID4,CD268 Antigen,BAFF Receptor,B-Cell Activation Factor Receptor,BAFF-R,TNF Receptor Superfamily Member 13C,BLyS Receptor 3,B-Cell-Activating Factor Receptor,TNFRSF13C
上市药物数量:0
临床药物数量:1
最高研发阶段:临床三期

Licensing 项目合作

项目名称 适应症 项目阶段 合作需求
BIA202201 B细胞恶性肿瘤、自身免疫性疾病 CMC阶段 寻求项目转让或者合作开发

BAFFR 分子别名

BAFFR,TNFRSF13C,BROMIX,CD268,CVID4,prolixin,BAFF-R

BAFFR 分子背景

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

BAFFR 前沿进展

BAFFR临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AUR-200 AUR-200 临床一期 Thunderbolt Pharma Inc 自身免疫疾病 详情
Ianalumab NOV-5; VAY-736 临床三期 Morphosys Ag, 诺华制药 血液肿瘤, 类风湿关节炎, 特发性肺纤维化, Sjtoegren综合征, 弥漫性大B-细胞淋巴瘤, 多发性硬化, 狼疮肾炎, 系统性红斑狼疮, 自身免疫性肝炎, 非霍奇金淋巴瘤, 慢性淋巴细胞白血病, 天疱疮 详情

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