Recombinant Proteins iso9001 ISO13485
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CD73信息

英文名称:5'-nucleotidase
中文名称:5'-核苷酸酶
靶点别称:CD73,5'-NT,NT5,NTE,Ecto-5'-nucleotidase,NT5E,5'-Nucleotidase Ecto,Ecto-5-Nucleotidase,5-NT,Purine 5-Prime-Nucleotidase,5-Nucleotidase, Ecto (CD73),5 Nucleotidase (CD73),5-Nucleotidase Ecto,5-Nucleotidase,CD73 Antigen,EC 3.1.3.5,CALJA,E5NT,ENT,NT,EN,EC:3.1
上市药物数量:0
临床药物数量:8
最高研发阶段:临床二期

CD73产品列表

 
评论(2)
CD3-M52H9|Mouse CD73 / NT5E Protein, His Tag (active enzyme)
  1. 182XXXXXXX2
  2. 1人赞
  3. Mouse CD73到货后就立即开始使用啦,虽然是鼠的,但是与抗体的结合力依然很强,BLI数据显示亲和力有6E-10.
  4. >
  5. 2020-01-10
CD3-H52H7|Human CD73 / NT5E Protein, His Tag (HPLC-verified) (active enzyme)
  1. 182XXXXXXX2
  2. 2人赞
  3. Human CD73用来检测medimmune家的抗体与其亲和力,结果具有很高的亲和力,亲和力为5E-10.
  4. >
  5. 2020-01-10
 

CD73 Molecule Synonym Name

CD73,NT5E,5'-Nucleotidase,5'-NT,NT5,NTE

CD73 分子背景

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.

CD73 参考文献

CD73临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
TJ-004309 TJD-5; TJ-4309; TJ-004309 临床二期 天境生物科技(上海)有限公司 肿瘤, 转移癌 详情
Anti-CD73 monoclonal antibody (Bristol-Myers Squibb) 临床一期 百时美施贵宝 肿瘤
LY-3475070 LY-3475070 临床一期 礼来制药 肿瘤 详情
Oleclumab MEDI-9447 临床二期 Medimmune Llc 实体瘤, 卵巢癌, 癌, 胰腺癌, 三阴性乳腺肿瘤, 膀胱癌, 前列腺癌, 乳腺癌, 结直肠癌, 非小细胞肺癌 详情
CPI-006 CPI-006 临床三期 Corvus 卵巢癌, 肾细胞癌, 头颈部鳞状细胞癌, 三阴性乳腺肿瘤, 胰腺癌, 新型冠状病毒肺炎, 膀胱癌, 肉瘤, 前列腺癌, 结直肠癌, 非霍奇金淋巴瘤, 子宫内膜样癌, 非小细胞肺癌, 宫颈癌 详情
BMS-986179 BMS-986179 临床二期 百时美施贵宝 实体瘤 详情
SRF-373 NZV-930; SRF-373 临床一期 Surface Oncology 实体瘤, 卵巢癌, 肾细胞癌, 三阴性乳腺肿瘤, 前列腺癌, 结直肠癌, 胰腺导管癌, 非小细胞肺癌 详情
AB-680 AB-680 临床二期 Arcus Biosciences 胰腺癌, 去势抵抗性前列腺肿瘤, 前列腺癌, 结直肠癌 详情

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