CD73 靶点蛋白|抗体药物|临床药物信息

CD73信息

英文名称：5'-nucleotidase
中文名称：5'-核苷酸酶
靶点别称：5' Nucleotidase (CD73)，5'-nucleotidase，5'-Nucleotidase， Ecto (CD73)，Ecto-5'-nucleotidase，NT5E，5'-Nucleotidase Ecto，Ecto-5-Nucleotidase，5-NT，Purine 5-Prime-Nucleotidase，5-Nucleotidase， Ecto (CD73)，5 Nucleotidase (CD73)，5-Nucleotidase Ecto，5-Nucleotidase，CD73 Antigen，EC 3.1.3.5，CALJA，E5NT，ENT，NT，EN，CD73，5'-NT，NT5，NTE，EC:3.1.3.5

上市药物数量：0
临床药物数量：15
最高研发阶段：临床三期

CD73产品列表

筛选结果

产品库

在线 (9)

物种

标签

属性

标记

货号	物种	产品描述
CD3-H52H7	Human	Human CD73 / NT5E Protein, His Tag (HPLC-verified) (active enzyme)
CD3-M52H9	Mouse	Mouse CD73 / NT5E Protein, His Tag (active enzyme)
CD3-H82E3	Human	Biotinylated Human CD73 / NT5E Protein, His,Avitag™
CD3-H5252	Human	Human CD73 Protein, Mouse IgG2a Fc Tag (active enzyme)
CD3-C52H9	Cynomolgus	Cynomolgus CD73 Protein, His Tag (active enzyme)
MBS-K022	Human	Human CD73-coupled Magnetic Beads
CD3-C52H5	Canine	Canine CD73 / NT5E Protein, His Tag (MALS verified) (active enzyme)
CD3-S52H3	Sus scrofa (Pig)	Sus scrofa CD73 / NT5E Protein, His Tag (active enzyme, MALS verified)
CD3-R52H3	Rabbit	Rabbit CD73 / NT5E Protein, His Tag (active enzyme)

CD3-H52H7|Human CD73 / NT5E Protein, His Tag (HPLC-verified) (active enzyme)

182XXXXXXX2

5人赞

Human CD73用来检测medimmune家的抗体与其亲和力，结果具有很高的亲和力，亲和力为5E-10.
>
2020-01-10

CD3-M52H9|Mouse CD73 / NT5E Protein, His Tag (active enzyme)

182XXXXXXX2

3人赞

Mouse CD73到货后就立即开始使用啦，虽然是鼠的，但是与抗体的结合力依然很强，BLI数据显示亲和力有6E-10.
>
2020-01-10

CD3-H52H7|Human CD73 / NT5E Protein, His Tag (HPLC-verified) (active enzyme)

139XXXXXXX9

3人赞

最近在建CD73单抗结合活性的检测方法，使用了这个His标签的CD73蛋白，S型曲线最大值明显高于其他公司CD73，窗口值也符合实验要求，后续会继续支持ACRO的。
2020-07-03

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CD73 分子别名

CD73,NT5E,5'-Nucleotidase,5'-NT,NT5,NTE

CD73 分子背景

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.

CD73 前沿进展

CD73临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Anti-CD73 monoclonal antibody (Bristol-Myers Squibb)		临床一期		肿瘤	详情
BR-101	BR101; BR-101	临床一期	浙江博锐生物制药有限公司	实体瘤	详情
SRF-373(Surface Oncology)	SRF-373; NZV-930		Surface Oncology		详情
IPH-5301	IPH-5301	临床一期	Innate Pharma	食道癌, 胃癌, 肿瘤, 胰腺癌, 乳腺癌, 子宫内膜癌, 肺癌, 转移癌	详情
IBI-325	IBI-325	临床一期	信达生物制药（苏州）有限公司	实体瘤	详情
INCA-00186	INCA-00186		Incyte Corp Ltd		详情
Uliledlimab	TJ-004309; TJD-5; TJ-4309	临床二期	天境生物科技（上海）有限公司	实体瘤	详情
BMS-986179	BMS-986179		百时美施贵宝		详情
LY-3475070	LY-3475070		礼来制药		详情
Dalutrafusp alfa	GS-1423; AGEN-1423		吉利德		详情
PT-199	PT-199	临床一期	Phanes Therapeutics Inc	实体瘤, 肿瘤, 转移癌	详情
Mupadolimab	CPI-006	临床二期	Corvus	头颈癌, 卵巢癌, 肾细胞癌, 头颈部鳞状细胞癌, 人乳头瘤病毒感染, 三阴性乳腺肿瘤, 胰腺癌, 新型冠状病毒肺炎, 膀胱癌, 肉瘤, 前列腺癌, 结直肠癌, 子宫内膜癌, 非霍奇金淋巴瘤, 非小细胞肺癌, 宫颈癌	详情
PM-1015	PM1015; PM-1015	临床一期	普米斯生物技术（珠海）有限公司	实体瘤	详情
Quemliclustat	AB-680	临床二期	Arcus Biosciences Inc, Gilead Sciences Inc	胰腺癌, 去势抵抗性前列腺肿瘤, 结直肠癌	详情
Oleclumab	MEDI-9447	临床三期	Medimmune Llc	实体瘤, 头颈部鳞状细胞癌, 转移性上皮癌, 肾细胞癌, 三阴性乳腺肿瘤, 胰腺癌, 肿瘤, 膀胱癌, 前列腺癌, 结直肠癌, 胰腺导管癌, 非小细胞肺癌	详情
Dresbuxelimab	AK-119	临床一期	Akeso Pharmaceuticals Inc	实体瘤, 新型冠状病毒肺炎, 特发性肺纤维化	详情
JAB-BX102	JAB-BX102	临床二期	北京加科思新药研发有限公司	实体瘤	详情
CB-708	CB-708; CB708; ATG-037	临床一期	Calithera Biosciences Inc	实体瘤, 肿瘤	详情

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CD73