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NS1信息

英文名称:Src homology phosphotyrosyl phosphatase 2
中文名称:蛋白酪氨酸磷酸酶-2
靶点别称:Protein Tyrosine Phosphatase Non-Receptor Type 11,SHP-2,PTP2C,Protein-tyrosine phosphatase 2C,PTP-2C,PTP-1D,SH-PTP3,PTPN11,Protein-Tyrosine Phosphatase 1D,SH-PTP2,EC:3.1.3.48,Noonan Syndrome 1,EC 3.1.3.48,METCDS,SHPTP2,BPTP3,JMML,SHP2,CFC,NS1,Protein Tyrosine Phosphatase, Non-Receptor Type 11,Tyrosine-Protein Phosphatase Non-Receptor Type 11
上市药物数量:0
临床药物数量:11
最高研发阶段:临床二期

NS1 分子别名

NS1

NS1 分子背景

Zika virus (ZIKV) is a member of the virus family Flaviviridae and the genus Flavivirus, transmitted by daytime-active Aedes mosquitoes, such as A. aegypti and A. albopictus. Its name comes from the Zika Forest of Uganda, where the virus was first isolated in 1947. Zika virus is related to dengue, yellow fever, Japanese encephalitis, and West Nile viruses. The infection, known as Zika fever, often causes no or only mild symptoms, similar to a mild form of dengue fever. It is treated by rest. Since the 1950s, it has been known to occur within a narrow equatorial belt from Africa to Asia. As of 2016, the illness cannot be prevented by drugs or vaccines. As of February 2016, there is evidence that Zika fever in pregnant women is associated with abnormal brain development in their fetuses through mother-to-child transmission of the virus, which may result in miscarriage or microcephaly.

NS1 前沿进展

NS1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
ERAS-601 ERAS-601 临床一期 Erasca Inc 实体瘤 详情
SH-3809 SH3809 临床一期 南京圣和药业股份有限公司 实体瘤 详情
RG-6433 RG-6433 临床一期 基因泰克 实体瘤 详情
ICP-189 ICP-189 临床一期 诺诚健华医药有限公司 实体瘤 详情
RLY-1971 RLY-1971 临床一期 Relay Therapeutics Inc 实体瘤 详情
BBP-398 IACS-15509; BBP-398; IACS-13909 临床一期 Bridgebio Pharma Inc, 德州大学安德森癌症中心 实体瘤 详情
JAB-3312 JAB-3312 临床二期 北京加科思新药研发有限公司, 艾伯维 实体瘤, 头颈部鳞状细胞癌, 乳腺癌, 结直肠癌, 胰腺导管癌, 食管鳞状细胞癌, 非小细胞肺癌 详情
JAB-3068 JAB-3068 临床二期 北京加科思新药研发有限公司, 艾伯维 头颈癌, 实体瘤, 头颈部鳞状细胞癌, 食道癌, 食管鳞状细胞癌, 非小细胞肺癌 详情
GH-21 GH-21; HBI-2376 临床一期 勤浩医药(苏州)有限公司 实体瘤, 结肠癌, 胰腺癌, 结直肠癌, 非小细胞肺癌 详情
BPI-442096 临床一期 贝达药业股份有限公司 实体瘤 详情
RMC-4630 RMC-4630; SAR-442720 临床二期 Revolution Medicines Inc, 赛诺菲 实体瘤, 转移癌, 非小细胞肺癌 详情
TNO-155 TNO-155 临床二期 诺华制药 实体瘤, 头颈部鳞状细胞癌, 结直肠癌, 胃肠道间质瘤, 肺癌, 食管鳞状细胞癌, 非小细胞肺癌, 黑色素瘤, 转移癌 详情
ET-0038 ET-0038 临床一期 上海奕拓医药科技有限责任公司 实体瘤 详情

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