DDR2 分子别名
DDR2,CD167b,NTRKR3,TKT,TYRO10
DDR2 分子背景
Discoidin domain-containing receptor 2 (DDR2) is also known as CD167 antigen-like family member B (CD167b), Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3(NTRKR3), Tyrosine-protein kinase TYRO10, Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. DDR2 is required for normal bone development. DDR2 regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. DDR2 regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. DDR2 promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
DDR2 前沿进展
- Gibbs R.A., et al., 2007, Science 316:222-234.
- Xu L., et al., 2007, Arthritis Rheum. 56:2663-2673.
- Konitsiotis A.D., et al., 2008, J. Biol. Chem. 283:6861-6868.
- Konitsiotis A.D., et al., 2008, J. Biol. Chem. 283:6861-6868.
膜杰作
Star Staining
ViruStop
Aneuro
ComboX
ActiveMax
GENPower
ClinMax
Star Ribbon
