登录 | 注册    关注公众号  
微信公众号
搜索

VLDL R产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
VLR-H5227
Human
Human VLDL R Protein, His Tag
 
评论(0)
 

VLDL R 分子别名

VLDLR,RP11-320E16.1,CHRMQ1,FLJ35024,VLDLRCH,VLDL receptor

VLDL R 分子背景

The very-low-density-lipoprotein receptor (VLDL-R) is a lipoprotein receptor that shows considerable similarity to the lowdensity-lipoprotein receptor. VLDL R is a 130 kDa type I transmembrane protein in the LDL receptor family that plays a significant role in lipid metabolism and in nervous system development and function .This receptor has been suggested to be important for the metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, such as very-low-densitylipoprotein (VLDL), beta-migrating VLDL and intermediate-density lipoprotein. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity. In humans, the VLDL-R is encoded by the VLDLR gene.A rare neurological disorder first described in the 1970s under the name "disequilibrium syndrome" is now considered to be caused by the disruption of VLDLR gene. The disorder was renamed VLDLR-associated cerebellar hypoplasia (VLDLRCH) after a 2005 study. It is associated with parental consanguinity and found in secluded communities such as the Hutterites. VLDLRCH is one of the two known genetic disorders caused by a disruption of reelin signaling pathway, along with Norman-Roberts syndrome.

VLDL R 前沿进展

消息提示

请输入您的联系方式,再点击提交!

确定