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VEGF-C信息

英文名称:Vascular endothelial growth factor C
中文名称:血管内皮生长因子C
靶点别称:Vascular Endothelial Growth Factor-Related Protein,Flt4-L,VRP,FLT4 Ligand DHM,LMPH1D,VEGF-C,Vascular Endothelial Growth Factor C,Flt4 ligand,VEGFC,LMPHM4
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

VEGF-C产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
VEC-H4225
Human
Human VEGF-C / Flt4-L Protein, His Tag
 
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VEGF-C 分子别名

VEGFC,Flt4-L,VRP

VEGF-C 分子背景

Vascular endothelial growth factor C is also known as VEGFC, Flt4-L and VRP, it contains the C-terminal propeptide which has an unusual structure with tandemly repeated cysteine-rich motifs. Upon biosynthesis, VEGFC is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGFC is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor D (VEGF-D). VEGFC may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Overexpression of VEGF-C causes lymphatics to enlarge possibly facilitates metastasis.

VEGF-C 参考文献

VEGF-C临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
VEGF-C gene therapy (Herantis Pharma) LX-1101; Ad-VEGF-C 临床二期 Herantis Pharma 淋巴水肿 详情
OPT-302 OPT-302; VGX-300 临床三期 Orphan Europe Sarl 病理性新生血管, 视网膜病变, 糖尿病黄斑水肿, 视网膜变性, 年龄相关性黄斑变性 详情

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