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 > 【VEGF-B】重组蛋白信息

VEGF-B信息

英文名称:Vascular endothelial growth factor B
中文名称:血管内皮生长因子B
靶点别称:VEGF-related factor,VRF,VEGFB,VEGF-B,VEGFL,Vascular Endothelial Growth Factor B
上市药物数量:0
临床药物数量:2
最高研发阶段:临床一期

VEGF-B产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
VE6-H5225
Human
Human VEGF-B Protein, His Tag
 
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VEGF-B 分子别名

VRF,VEGFL,VEGFB,VEGF-B

VEGF-B 分子背景

Vascular endothelial growth factor B (VEGFB) is also known as VEGF-related factor (VRF), is a secreted O-glycosylated protein, which belongs to the PDGF/VEGF growth factor family. VEGFB is expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. VEGFB is growth factor for endothelial cells. VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. VEGF-B also plays an important role on several types of neurons. It is important for the protection of neurons in the retina and the cerebral cortex during stroke and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis.VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

VEGF-B 参考文献

VEGF-B临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AAV.7m8-aflibercept (Adverum Biotechnologies) ADVM-022 临床一期 Adverum Biotechnologies 年龄相关性黄斑变性 详情
CSL-346 2H-10; CSL-346 临床一期 Csl Ltd 二型糖尿病, 糖尿病肾病 详情

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