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IL-4信息

英文名称:Interleukin-4
中文名称:白细胞介素-4
靶点别称:MGC79402,B-cell stimulatory factor 1,Lymphocyte stimulatory factor 1,IL4,Interleukin 4,B_cell Stimulatory Factor 1,B Cell Growth Factor 1,Binetrakin,Pitrakinra,BSF-1,IL-4,Interleukin 4 Variant 2,BCGF-1,BCGF1,BSF1,Interleukin-4
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

IL-4产品列表

 
评论(4)
IL4-H82E0|Biotinylated Human IL-4 Protein, Avitag™,His Tag (MALS verified)
  1. 177XXXXXXX7
  2. 4人赞
  3. 购买蛋白为human-il4,作为octect亲和力测试用。
  4. >
  5. 2022-02-19
IL4-H82E0|Biotinylated Human IL-4 Protein, Avitag™,His Tag (MALS verified)
  1. 139XXXXXXX3
  2. 3人赞
  3. 用于抗体筛选工作,抗原包被效果良好,目前实验顺利进行中,提供的技术支持也比较完善,试验中出现的问题都能给予多方面的支持
  4. 2022-01-05
IL4-H4218|ActiveMax® Human IL-4 Protein, Tag Free
  1. 156XXXXXXX8
  2. 2人赞
  3. 购买该蛋白用于巨噬细胞诱导,开展巨噬细胞相关功能性验证实验,在添加M-CSF和IL-4的情况下,可以诱导PBMC和THP1细胞分化成为具有免疫抑制作用的M2型巨噬细胞。
  4. 2021-08-19
 

IL-4 分子别名

IL4,BCGF1,BSF1

IL-4 分子背景

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

IL-4 前沿进展

IL-4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Dectrekumab/VAK-694 QBX-258 临床二期 诺华制药 淋巴水肿, 哮喘 详情
OCH-NCNP1 OCH-NCNP1 临床二期 庆应义塾大学 多发性硬化, 克罗恩病 详情
DMT-210 DMT-200; DMT-210; DMT-220; SIG-990 Signum Dermalogix 详情
AIR-645 AIR-645; ISIS-369645 Ionis Pharmaceuticals Inc 详情
Romilkimab SUB-33159; SAR-156597 赛诺菲 详情
GSK-2434735 GSK-2434735 葛兰素史克 详情
VAK-694 VAK-694; NVP-VAK-694 诺华制药 详情
Berdazimer sodium NVN1000-SB206; MAP3-NONOate - SB-206; SB-019; NVN-1000-SB-206-Novan; SB-206 Novan 详情

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