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> 【IL-4】
IL-4信息
英文名称：Interleukin-4
中文名称：白细胞介素-4
靶点别称：MGC79402，B-cell stimulatory factor 1，Lymphocyte stimulatory factor 1，IL4，Interleukin 4，B_cell Stimulatory Factor 1，B Cell Growth Factor 1，Binetrakin，Pitrakinra，BSF-1，IL-4，Interleukin 4 Variant 2，BCGF-1，BCGF1，BSF1，Interleukin-4
中文名称：白细胞介素-4
靶点别称：MGC79402，B-cell stimulatory factor 1，Lymphocyte stimulatory factor 1，IL4，Interleukin 4，B_cell Stimulatory Factor 1，B Cell Growth Factor 1，Binetrakin，Pitrakinra，BSF-1，IL-4，Interleukin 4 Variant 2，BCGF-1，BCGF1，BSF1，Interleukin-4
上市药物数量：0
临床药物数量：4
最高研发阶段：临床二期
临床药物数量：4
最高研发阶段：临床二期
IL-4产品列表
评论(4)
IL4-H82E0|Biotinylated Human IL-4 Protein, Avitag™,His Tag (MALS verified)
- 177XXXXXXX7
- 购买蛋白为human-il4，作为octect亲和力测试用。
-
> - 2022-02-19
4人赞
IL4-H82E0|Biotinylated Human IL-4 Protein, Avitag™,His Tag (MALS verified)
- 139XXXXXXX3
- 用于抗体筛选工作，抗原包被效果良好，目前实验顺利进行中，提供的技术支持也比较完善，试验中出现的问题都能给予多方面的支持
- 2022-01-05
3人赞
IL4-H4218|ActiveMax® Human IL-4 Protein, Tag Free
- 156XXXXXXX8
- 购买该蛋白用于巨噬细胞诱导，开展巨噬细胞相关功能性验证实验，在添加M-CSF和IL-4的情况下，可以诱导PBMC和THP1细胞分化成为具有免疫抑制作用的M2型巨噬细胞。
- 2021-08-19
2人赞
IL-4 分子别名
IL4,BCGF1,BSF1
IL-4 分子背景
Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.
IL-4 前沿进展
IL-4临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| Dectrekumab/VAK-694 | QBX-258 | 临床二期 | 诺华制药 | 淋巴水肿, 哮喘 | 详情 |
| OCH-NCNP1 | OCH-NCNP1 | 临床二期 | 庆应义塾大学 | 多发性硬化, 克罗恩病 | 详情 |
| DMT-210 | DMT-200; DMT-210; DMT-220; SIG-990 | Signum Dermalogix | 详情 | ||
| AIR-645 | AIR-645; ISIS-369645 | Ionis Pharmaceuticals Inc | 详情 | ||
| Romilkimab | SUB-33159; SAR-156597 | 赛诺菲 | 详情 | ||
| GSK-2434735 | GSK-2434735 | 葛兰素史克 | 详情 | ||
| VAK-694 | VAK-694; NVP-VAK-694 | 诺华制药 | 详情 | ||
| Berdazimer sodium | NVN1000-SB206; MAP3-NONOate - SB-206; SB-019; NVN-1000-SB-206-Novan; SB-206 | Novan | 详情 |
