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TNFR2信息

英文名称:Tumor necrosis factor receptor superfamily member 1B
中文名称:肿瘤坏死因子受体2
靶点别称:TNFR-II,TNFR80,TNF-RII,p80 TNF-alpha receptor,p75,Tumor necrosis factor receptor 2,Etanercept,TBP-2,Tumor necrosis factor receptor type II,TBPII,CD120b,TNF-R-II,CD120b Antigen,Tumor Necrosis Factor Beta Receptor,Soluble TNFR1B Variant 1,Tumor Necrosis Factor Binding Protein 2,TNFBR,TNF Receptor Superfamily Member 1B,TNFR2,P75 TNF Receptor,P75TNFR,TNFR1B,Tumor Necrosis Factor Receptor Superfamily, Member 1B,TNF-R75,TNF-R2
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

TNFR2产品列表

 
评论(3)
TN2-H82E3|Biotinylated Human TNFR2 / CD120b / TNFRSF1B Protein, His,Avitag™ (MALS verified)
  1. 153XXXXXXX5
  2. 0人赞
  3. 我们购买的是一款经生物素标记的Human TNFR2(TN2-H82E3)蛋白,用于抗体筛选。在此项目中用于基于ELISA实验的阻断实验检测,这款蛋白的实验数据非常稳定,分装后可以冻存保存很久仍然维持很不错的亲和活性,用于阻断实验没有问题。
  4. 2022-05-21
TN2-H5227|Human TNFR2 / CD120b / TNFRSF1B Protein, His Tag
  1. 153XXXXXXX5
  2. 0人赞
  3. 我们购买的是一款Human TNFR2(TN2-H5227)蛋白,用于小鼠免疫和抗体筛选。可以免疫获得较好的效价,同时与人合猴蛋白交叉反应。另外该蛋白与TNFa配体蛋白的结合曲线数据,与官网数据基本一致。
  4. 2022-05-21
TN2-M52H8|Mouse TNFR2 / CD120b / TNFRSF1B Protein, His Tag
  1. 153XXXXXXX5
  2. 0人赞
  3. 我们购买的是一款Mouse TNFR2(TN2-M52H8)蛋白,用于抗体发现项目中用于基于ELISA实验的小鼠血清反应种属交叉检测,这款小鼠蛋白经过ELISA实验验证,可以和兔抗鼠TNFR2抗体有结合,活性OK。
  4. 2022-05-21
 

TNFR2 分子别名

TNFRSF1B,CD120b,TBPII,TNF-R-II,TNF-R75,TNFBR,TNFR1B,TNFR2,TNFR80,p75,p75TNFR

TNFR2 分子背景

TNF RI is also known as the p60 or p55 TNFR) and TNF RII (the p75 or p80 TNFR) are two distinct type I transmembrane glycoproteins that bind TNF with highaffinity.Both RI and RII are prototypic members of the TNF receptor superfamily and have been designated TNFRSF1A and TNFRSF1B, respectively. Human TNF RII cDNA encodes a 461 amino acid (aa) residue precursor protein with a 22 aa putative signal peptide, a 235 aa extracellular domain, a 20 aa transmembrane domain and a 174 aa cytoplasmic domain. TNFRII is expressed in fetal brain. The protein is produced naturally as a soluble form (sTNFRII). The soluble receptor inhibits TNFα action by competing with cell surface receptors in binding TNFα, thereby blocking its biologic effects. TNFRII is strongly expressed at the cartilage–pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). Further, high plasma levels of sTNFRII were significantly associated with increased incidence of coronary heart disease, independent of established cardiovascular risk factors, and seems to be useful for monitoring the inflammatory activity of sarcoidosis.

TNFR2 前沿进展

TNFR2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
SIM1811-03 SIM1811-03; SIM0235; SIM-235 临床一期 江苏先声药业有限公司 实体瘤, 皮肤T细胞淋巴瘤 详情
HFB-2003(HiFiBiO Therapeutics) HFB-2003; HFB-200301 高诚生物 详情
LBL-019 LBL-019 临床二期 南京维立志博生物科技有限公司 肿瘤 详情

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