TNFR1 靶点蛋白|抗体药物|临床药物信息

TNFR1信息

英文名称：Tumor necrosis factor receptor superfamily member 1A
中文名称：肿瘤坏死因子受体1型
靶点别称：Tumor necrosis factor receptor 1，TNF-R1，Tumor necrosis factor receptor type I，TNF-RI，TNFR-I，CD120a，TNF Receptor Superfamily Member 1A，TNFAR，Tumor Necrosis Factor Receptor Superfamily Member 1A，TNF-R-I，TNF-R55，TNFR60，TNF-R，TNFR1，Tumor Necrosis Factor Receptor Superfamily， Member 1A，Tumor Necrosis Factor Receptor 1A Isoform Beta，Tumor Necrosis Factor Binding Protein 1，Tumor Necrosis Factor Receptor Type 1，Tumor Necrosis Factor Receptor Type I，Tumor Necrosis Factor-Alpha Receptor，Tumor Necrosis Fac

上市药物数量：0
临床药物数量：1
最高研发阶段：临床二期

TNFR1产品列表

筛选结果

产品库

在线 (2)

物种

Human (2)

标签

属性

Protein (2)

标记

Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
TN1-H5222	Human	Human TNFR1 / CD120a / TNFRSF1A Protein, His Tag
TN1-H5251	Human	Human TNFR1 / CD120a / TNFRSF1A Protein, Fc Tag (MALS verified)

TN1-H5251|Human TNFR1 / CD120a / TNFRSF1A Protein, Fc Tag (MALS verified)

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1人赞

该产品用于药物发现高通量筛选，主要用于ELISA和FRET方法来进行高通量筛选，ACRO的TNFR1与其配体体具有很好的亲和力，使我们更加容易建立稳定的筛选体系。
2021-09-03

TNFR1 分子别名

TNFR1,CD120a,TNFRSF1A,FPF,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR55,TNFR60,p55,p60

TNFR1 分子背景

Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).

TNFR1 前沿进展

TNFR1临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
GSK-2862277	GSK-2862277; 2862277	临床二期	葛兰素史克	呼吸障碍, 成人呼吸窘迫综合征, 急性肺损伤	详情

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TNFR1