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TNFR1信息

英文名称:Tumor necrosis factor receptor superfamily member 1A
中文名称:肿瘤坏死因子受体1型
靶点别称:Tumor necrosis factor receptor 1,TNF-R1,Tumor necrosis factor receptor type I,TNF-RI,TNFR-I,CD120a,TNF Receptor Superfamily Member 1A,TNFAR,Tumor Necrosis Factor Receptor Superfamily Member 1A,TNF-R-I,TNF-R55,TNFR60,TNF-R,TNFR1,Tumor Necrosis Factor Receptor Superfamily, Member 1A,Tumor Necrosis Factor Receptor 1A Isoform Beta,Tumor Necrosis Factor Binding Protein 1,Tumor Necrosis Factor Receptor Type 1,Tumor Necrosis Factor Receptor Type I,Tumor Necrosis Factor-Alpha Receptor,Tumor Necrosis Fac
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

TNFR1产品列表

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评论(1)
TN1-H5251|Human TNFR1 / CD120a / TNFRSF1A Protein, Fc Tag (MALS verified)
  1. 185XXXXXXX0
  2. 1人赞
  3. 该产品用于药物发现高通量筛选,主要用于ELISA和FRET方法来进行高通量筛选,ACRO的TNFR1与其配体体具有很好的亲和力,使我们更加容易建立稳定的筛选体系。
  4. 2021-09-03
 

TNFR1 分子别名

TNFR1,CD120a,TNFRSF1A,FPF,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR55,TNFR60,p55,p60

TNFR1 分子背景

Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).

TNFR1 前沿进展

TNFR1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
GSK-2862277 GSK-2862277; 2862277 临床二期 葛兰素史克 呼吸障碍, 成人呼吸窘迫综合征, 急性肺损伤 详情

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