登录 | 注册    微信公众号  
搜索
 > 【IL-15】

IL-15信息

英文名称:Interleukin-15
中文名称:白细胞介素-15
靶点别称:IL-15,Interleukin-15,IL15,Interleukin 15,MGC9721
上市药物数量:0
临床药物数量:8
最高研发阶段:临床二期

IL-15产品列表

 
评论(1)
GMP-L15H13|GMP Human IL-15
  1. 136XXXXXXX768
  2. 1人赞
  3. ACRO细胞因子在与现有细胞因子用量一致的情况下所制备的CART细胞扩增更好活率更高且转染效率方面与现使用的细胞因子无差别
  4. >
  5. 2022-05-23
 

IL-15 分子别名

IL-15,Interleukin-15,MGC9721

IL-15 分子背景

Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

IL-15 前沿进展

IL-15临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CALY-002 临床一期 Calypso Biotech Bv 乳糜泻, 嗜酸性粒细胞性食管炎 详情
CAR-5/IL-15-transduced CB-NK cell therapy 临床二期 德州大学安德森癌症中心 血液肿瘤 详情
Ordesekimab AMG-714; HuMab-IL15; PRV-015 临床二期 Genmab, Provention Bio, 安进 类风湿关节炎, 乳糜泻, 银屑病 详情
XmAb24306 XmAb-24306; RG-6323; RO-7310729; XmAb-306 临床一期 基因泰克, Xencor 实体瘤 详情
FT-536 FT-536 临床一期 Fate Therapeutics Inc 实体瘤 详情
Recombinant Human IL12/15-PDL1B Herpes Simplex Type I Oncolytic Virus(CNBG) VG-161 临床二期 中生复诺健生物科技(上海)有限公司 肝癌, 实体瘤, 胆管癌, 胆管上皮癌, 肝细胞癌 详情
RTX-240 RTX-240 临床二期 Rubius Therapeutics 急性早幼粒细胞白血病 详情
Heterodimeric interleukin 15(Novartis Pharma) NIZ-985 临床一期 诺华制药 实体瘤, 淋巴瘤, 黑色素瘤 详情
SAR-441000 SAR441000; SAR-441000; BNT-131 临床一期 Biontech Se, 赛诺菲 转移癌 详情
BNZ-2 BNZ-2 临床一期 Bioniz 乳糜泻 详情

消息提示

请输入您的联系方式,再点击提交!

确定