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IL-15信息

英文名称:Interleukin-15
中文名称:白细胞介素-15
靶点别称:IL-15,Interleukin-15,IL15,Interleukin 15,MGC9721
上市药物数量:0
临床药物数量:8
最高研发阶段:临床二期

IL-15产品列表

 
评论(3)
GMP-L15H13|GMP Human IL-15
  1. 136XXXXXXX768
  2. 2人赞
  3. ACRO细胞因子在与现有细胞因子用量一致的情况下所制备的CART细胞扩增更好活率更高且转染效率方面与现使用的细胞因子无差别
  4. >
  5. 2022-05-23
GMP-L15H13|GMP Human IL-15
  1. 180XXXXXXX5
  2. 0人赞
  3. ACRO细胞因子在所制备的TCRT细胞扩增更好活率更高且转染效率也有所提升,最终杀伤功能也增强。 图片中B培养体系采用ACRO IL15+IL21培养体系
  4. >
  5. 2022-07-21
IL5-H4117|Human IL-15 Protein, premium grade
  1. 130XXXXXXX1
  2. 0人赞
  3. 人重组白介素15细胞因子是我们常用的细胞体外培养所需的生物试剂,主要用于细胞活化扩增,所以这款高质量的细胞因子对细胞培养功不可没
  4. >
  5. 2022-08-03
 

IL-15 分子别名

IL-15,Interleukin-15,MGC9721

IL-15 分子背景

Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

IL-15 前沿进展

IL-15临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
VG-201 VG-201 临床一期 复诺健生物技术有限公司 食道癌, 胃癌, 结直肠癌, 非小细胞肺癌 详情
Recombinant Human IL12/15-PDL1B Herpes Simplex Type I Oncolytic Virus(CNBG) VG-161 临床二期 肝癌, 实体瘤, 胆管癌, 食道癌, 肿瘤 详情
CALY-002 临床一期 Calypso Biotech Bv 嗜酸性粒细胞性食管炎, 乳糜泻 详情
Heterodimeric interleukin 15(Novartis Pharma) NIZ-985 诺华制药 详情
RTX-240 RTX-240 Rubius Therapeutics 详情
Ordesekimab HuMab-IL15; AMG-714; PRV-015 Provention Bio, Genmab, 安进 详情
SAR-441000 SAR441000; SAR-441000; BNT-131 Biontech Se, 赛诺菲 详情
CAR-5/IL-15-transduced CB-NK cell therapy 临床二期 MD Anderson Cancer Center 血液肿瘤 详情
XmAb24306 XmAb-24306; RG-6323; RO-7310729; XmAb-306 临床一期 基因泰克, Xencor 实体瘤, 肿瘤, 多发性骨髓瘤 详情
CYTO-102 CYTO-NK-102; CYTO-102 临床一期 CytoImmune Therapeutics Inc 非小细胞肺癌 详情
HCW-9218 HCW-9218 临床二期 HCW Biologics Inc 实体瘤, 胰腺癌, 肺纤维化 详情

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