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IL-15信息

英文名称:Interleukin-15
中文名称:白细胞介素-15
靶点别称:IL-15,Interleukin-15,IL15,Interleukin 15,MGC9721
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

IL-15 Molecule Synonym Name

IL-15,Interleukin-15,MGC9721

IL-15 分子背景

Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

IL-15 参考文献

IL-15临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
BJ-001 BJ-001 临床一期 博际生物医药科技(杭州)有限公司 传染性疾病, 肿瘤 详情
AMG-714 AMG-714; PRV-015; HuMab-IL15 临床二期 Genmab 类风湿关节炎, 银屑病, 乳糜泻 详情
Recombinant human interleukin 15(Beijing Kawin) 临床一期 北京凯因科技股份有限公司 实体瘤
XmAb24306 XmAb-24306; RG-6323; RO-7310729 临床一期 Xencor 肿瘤 详情
CALY-002 临床一期 Calypso Biotech Bv 嗜酸性粒细胞性食管炎, 乳糜泻 详情

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