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Stathmin 1信息

英文名称:Stathmin
中文名称:Stathmin蛋白
靶点别称:Protein Pr22,Phosphoprotein p19,LAP18,C1orf215,STMN1,Stathmin 1,Oncoprotein 18,Leukemia-Associated Phosphoprotein P18,Stathmin 1/Oncoprotein 18,Metablastin,Prosolin,Chromosome 1 Open Reading Frame 215,Testicular Tissue Protein Li 189,Transmembrane Protein C1orf215,Phosphoprotein 19,Stathmin,PP17,PR22,Op18,Pp19,Lag,SMN,FLJ32206
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

Stathmin 1产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
ST1-H5149
Human
Human Stathmin 1 / STMN1 Protein, His Tag
 
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Stathmin 1 分子别名

STMN1,Stathmin,C1orf215,LAP18,OP18

Stathmin 1 分子背景

Stathmin (STMN1), a member of the stathmin family, is also known as Leukemia-associated phosphoprotein p18, Oncoprotein 18 (Op18), Phosphoprotein p19 (pp19), Protein Pr22 and pp17, which contains one SLD (stathmin-like) domain. The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized. Stathmin (STMN1) interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization, there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.

Stathmin 1 前沿进展

Stathmin 1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
pbi-shRNA STMN1 Lipoplex 临床一期 Gradalis 实体瘤 详情

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