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SOD1信息

英文名称:Superoxide dismutase
中文名称:超氧化物歧化酶
靶点别称:SOD1,Superoxide Dismutase 1,HSod1,Amyotrophic Lateral Sclerosis 1 (Adult),Epididymis Secretory Protein Li 44,Superoxide Dismutase [Cu-Zn],Cu/Zn Superoxide Dismutase,Indophenoloxidase A,SOD, Soluble,EC 1.15.1.1,HEL-S-44,IPOA,ALS1,SOD,ALS,Superoxide Dismutase,STAHP,EC:1.15.1.1,Superoxide Dismutase 1, Soluble,Superoxide Dismutase, Cystolic,Homodimer
上市药物数量:1
临床药物数量:8
最高研发阶段:批准上市

SOD1产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
SO1-H5148
Human
Human SOD1 / Cu-Zn SOD Protein, His Tag (active enzyme)
 
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SOD1 分子别名

SOD1,Superoxide dismutase 1,hSod1

SOD1 分子背景

Superoxide dismutase [Cu-Zn] (SOD1) is also known as superoxide dismutase 1 (hSod1), an enzyme that in humans is encoded by the SOD1 gene, located on chromosome 21. SOD1 can bind copper and zinc ions and is one of three superoxide dismutases responsible for destroying free superoxide radicals in the body. The encoded isozyme (SOD1) is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide. Furthermore, the mutations of SOD1 gene can result in a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord.

SOD1 前沿进展

SOD1上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Cupric Sulfate/Manganese sulfate/Selenious acid/Zinc Sulfate 硫酸铜/硫酸锰/亚硒酸/硫酸锌 批准上市 MULTRYS United States 营养补充 American Regent Inc 2020-07-02 营养补充 详情
Orgotein 批准上市 Gt Biopharma Inc Ontosein Spain 风湿性疾病, 膀胱炎, 辐射损伤 null 1996-01-01 膀胱炎, 辐射损伤, 风湿性疾病 详情

SOD1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
APB-102 APB-102 临床一期 University Of Massachusetts Medical School 肌萎缩性侧索硬化 详情
AEOL-10150 AEOL-10150 临床一期 Aeolus Pharmaceuticals 特发性肺纤维化, 肿瘤 详情
NI-005 AP-101 (AL-S Pharma); NI-005 Al-S Pharma Ag 详情
Avasopasem manganese GC-4419; KM-4419; M-40419; SC-72325A Galera, Metaphore Pharmaceuticals, Activbiotics 详情
BMX-010 BMX-010; MnTE-2-PyP; MnTE-2-PyP5+ 杜克大学 详情
Otaplimastat SP-8203 hydrochloride; SP8203 HCL; SP-8203 Shin Poong Pharmaceutical 详情
Bis-choline tetrathiomolybdate ATN-224; WTX-101; ALXN-1840 Wilson Therapeutics 详情
GC-4711 GC-4711 Galera 详情
Manganese sulfate NP-02 临床二期 Medesis Pharma Sa 新型冠状病毒肺炎, 辐射损伤 详情

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