SOD1 靶点蛋白|抗体药物|临床药物信息

SOD1信息

英文名称：Superoxide dismutase
中文名称：超氧化物歧化酶
靶点别称：SOD1，Superoxide Dismutase 1，HSod1，Amyotrophic Lateral Sclerosis 1 (Adult)，Epididymis Secretory Protein Li 44，Superoxide Dismutase [Cu-Zn]，Cu/Zn Superoxide Dismutase，Indophenoloxidase A，SOD， Soluble，EC 1.15.1.1，HEL-S-44，IPOA，ALS1，SOD，ALS，Superoxide Dismutase，STAHP，EC:1.15.1.1，Superoxide Dismutase 1， Soluble，Superoxide Dismutase， Cystolic，Homodimer

上市药物数量：2
临床药物数量：9
最高研发阶段：批准上市

SOD1产品列表

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物种

标签

His Tag (3)

属性

Protein (3)

标记

Unconjugated (3)

货号	物种	产品描述
SO1-H5148	Human	Human SOD1 / Cu-Zn SOD Protein, His Tag (active enzyme)
SO1-H51H3	Human	Human SOD1 / Cu-Zn SOD (G94A) Protein, His Tag
SO1-M51H6	Mouse	Mouse SOD1 / Cu-Zn SOD Protein, His Tag

SOD1分子别名

SOD1,Superoxide dismutase 1,hSod1

SOD1分子背景

Superoxide dismutase [Cu-Zn] (SOD1) is also known as superoxide dismutase 1 (hSod1), an enzyme that in humans is encoded by the SOD1 gene, located on chromosome 21. SOD1 can bind copper and zinc ions and is one of three superoxide dismutases responsible for destroying free superoxide radicals in the body. The encoded isozyme (SOD1) is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide. Furthermore, the mutations of SOD1 gene can result in a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord.

SOD1上市药物信息

英文名称	中文名称	研发代码	研发阶段	公司	最早商品名	最早批准国家	最早适应症	最早批准公司	最早批准日期	适应症	临床试验
Orgotein			批准上市	Gt Biopharma Inc	Ontosein	Spain	风湿性疾病, 膀胱炎, 辐射损伤	null	1996-01-01	膀胱炎, 辐射损伤, 风湿性疾病	详情
Cupric Sulfate/Manganese sulfate/Selenious acid/Zinc Sulfate	硫酸铜/硫酸锰/亚硒酸/硫酸锌		批准上市		MULTRYS	United States	营养补充	American Regent Inc	2020-07-02	营养补充	详情

SOD1临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Avasopasem manganese	GC-4419; KM-4419; M-40419; SC-72325A	临床三期	Galera Therapeutics Inc, Metaphore Pharmaceuticals Inc, Activbiotics Pharma Llc	头颈癌, 胰腺癌, 新型冠状病毒肺炎, 肾脏疾病, 食管炎, 口腔癌, 鳞状细胞癌, 口腔炎, 非小细胞肺癌	详情
Manganese sulfate	NP-02	临床二期	Medesis Pharma Sa	新型冠状病毒肺炎, 辐射损伤	详情
NI-005	AP-101 (AL-S Pharma); NI-005	临床一期	Al-S Pharma Ag	肌萎缩性侧索硬化	详情
APB-102	APB-102	临床一期	University Of Massachusetts Medical School	肌萎缩性侧索硬化	详情
AEOL-10150	AEOL-10150	临床一期	Aeolus Pharmaceuticals	特发性肺纤维化, 肿瘤	详情
GC-4711	GC-4711	临床二期	Galera Therapeutics Inc	胰腺癌, 非小细胞肺癌	详情
BMX-010	BMX-010; MnTE-2-PyP; MnTE-2-PyP5+	临床二期	杜克大学	寻常痤疮, 酒渣鼻, 银屑病, 特应性皮炎	详情
Bis-choline tetrathiomolybdate	ATN-224; WTX-101; ALXN-1840	临床三期	Wilson Therapeutics	威尔逊氏病, 多发性骨髓瘤, 前列腺癌, 黑色素瘤	详情

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SOD1