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SMAC信息

英文名称:Diablo homolog, mitochondrial
中文名称:DIABLO蛋白
靶点别称:Direct IAP-binding protein with low pI,Second mitochondria-derived activator of caspase,Smac,Diablo IAP-Binding Mitochondrial Protein
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

SMAC产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
DIO-H5129
Human
Human SMAC / Diablo Protein, His Tag
ACRO质量管理体系
 
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SMAC 分子别名

DIABLO,SMAC

SMAC 分子背景

Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

SMAC 前沿进展

SMAC临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
BI-891065 BI-891065 临床一期 Boehringer Ingelheim Gmbh 肿瘤, 非小细胞肺癌, 转移癌 详情

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