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SIRP alpha信息

英文名称:Signal-regulatory protein alpha
中文名称:信号调节蛋白α
靶点别称:SHPS-1,Macrophage fusion receptor,Brain Ig-like molecule with tyrosine-based activation motifs,MFR,Signal-regulatory protein alpha-1,Signal-regulatory protein alpha-2,CD172a,MyD-1 antigen,Sirp-alpha-3,MYD1,SIRPA,Signal Regulatory Protein Alpha,CD172 Antigen-Like Family Member A,Inhibitory Receptor SHPS-1,PTPNS1,SHPS1,SIRP,P84,Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs,Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1,Tyrosine-Protein Phosphatase Non-Recept
上市药物数量:2
临床药物数量:7
最高研发阶段:批准上市

SIRP alpha产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
SIA-H52A8
Human
Human SIRP alpha / CD172a Protein, Mouse IgG1 Fc Tag (MALS verified)
SIA-H5225
Human
Human SIRP alpha / CD172a Protein, His Tag (MALS verified)
SIA-HP252
Human
PE-Labeled Human SIRP alpha / CD172a Protein, Fc Tag (recommended for neutralizing assay)
SIA-H5251
Human
Human SIRP alpha / CD172a Protein, Fc Tag (MALS verified)
CDA-H82F2
Human
Biotinylated Human SIRP alpha / CD172a Protein, Fc,Avitag™ (MALS verified)
SIA-M5252
Mouse
Mouse SIRP alpha / CD172a Protein, Mouse IgG2a Fc Tag, low endotoxin
SIA-C52H7
Cynomolgus
Cynomolgus SIRP alpha / CD172a Protein, His Tag (MALS verified)
SIA-C5254
Cynomolgus
Cynomolgus SIRP alpha / CD172a Protein, Fc Tag
SIA-M5258
Mouse
Mouse SIRP alpha / CD172a Protein, Fc Tag (MALS verified)
SIA-M52H4
Mouse
Mouse SIRP alpha / CD172a Protein, His Tag
SIA-H82E0
Human
Biotinylated Human SIRP alpha / CD172a Protein, His,Avitag™ (MALS verified)
SIA-H82A3
Human
Biotinylated Human SIRP alpha / CD172a Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
SIA-C82E2
Cynomolgus
Biotinylated Cynomolgus SIRP alpha / CD172a Protein, His,Avitag™ (MALS verified)
SIA-M82E2
Mouse
Biotinylated Mouse SIRP alpha / CD172a Protein, His,Avitag™ (MALS verified)
SIA-MP2H6
Mouse
PE-Labeled Mouse SIRP alpha Protein, His Tag (Site-specific conjugation)
SIA-H5258
Human
Human SIRP alpha / CD172a (31-149) Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)
SIA-H5256
Human
Human SIRP alpha / CD172a Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)
SIA-R5255
Rat
Rat SIRP alpha / CD172a Protein, Fc Tag
 
评论(28)
CDA-H82F2|Biotinylated Human SIRP alpha / CD172a Protein, Fc,Avitag™ (MALS verified)
  1. 178XXXXXXX3
  2. 2人赞
  3. 我们公司购买的CD172蛋白,用于生物活性放行产品的检测。这个蛋白性能稳定,检测结果数据稳定,而且公司发货速度较快。
  4. 2019-10-11
SIA-H5225|Human SIRP alpha / CD172a Protein, His Tag (MALS verified)
  1. 177XXXXXXX7
  2. 1人赞
  3. 人源CD172a his标签蛋白,我们用于octect仪器检测抗体亲和力,proA探针固定抗体结合抗原,蛋白很稳定。
  4. >
  5. 2021-11-10
SIA-M82E2|Biotinylated Mouse SIRP alpha / CD172a Protein, His,Avitag™ (MALS verified)
  1. 152XXXXXXX0
  2. 1人赞
  3. 我们公司购买了Biotinylated Mouse SIRP alpha / CD172a Protein, His,Avitag™,主要目的是为了做免疫,靶点设计挺好的,实验结果出来了,结果很好,项目进展加快,物流第二天就到了,说明书很详细,销售人员也很专业,合作满意。
  4. 2022-01-20
 

SIRP alpha 分子别名

SIRP alpha,SHPS1,SIRPA,CD172A,BIT,SHPS-1,MFR,MYD-1,MYD1,PTPNS1,SIRPalpha,p84,SIRP-alpha,CD172

SIRP alpha 分子背景

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

SIRP alpha 前沿进展

SIRP alpha上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Elagolix/estradiol/norethindrone acetate 批准上市 艾伯维 Oriahnn United States 月经过多 Abbvie Inc 2020-05-29 月经过多 详情
Relugolix/Estradiol/Norethindrone Acetate 批准上市 Myovant Sciences MYFEMBREE United Kingdom 子宫肿瘤 Gedeon Richter 2021-05-26 平滑肌瘤, 月经过多, 子宫肿瘤 详情

SIRP alpha临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
GS-0189 FSI-189; GS-0189; FSI89 Gilead Sciences Inc 详情
TQB-2928 TQB-2928 临床一期 正大天晴药业集团股份有限公司 肿瘤 详情
[89Zr]Zr- BI-765063(Boehringer Ingelheim) Boehringer Ingelheim Corp 详情
ELA-026 ELA-026 Electra Therapeutics Inc 详情
AL-008 AL-008; IBI-397 临床一期 Alector 肿瘤 详情
BI-765063 OSE-172; BI-765063 临床一期 Ose Immunotherapeutics 实体瘤, 头颈部鳞状细胞癌, 结直肠癌, 非小细胞肺癌, 黑色素瘤 详情
RRx-001 ABDNAZ; RRx-001 临床三期 Epicentre Biotechnologies Llc 脑癌, 口腔炎, 非小细胞肺癌, 转移癌, 脑转移, 小细胞癌, 淋巴瘤, 结直肠癌, 胆管上皮癌, 实体瘤, 神经内分泌瘤, 中枢神经系统肿瘤, 少突神经胶质瘤, 卵巢上皮癌, 肿瘤, 小细胞肺癌, 胶质母细胞瘤 详情
CC-95251 CC-95251 临床一期 Celgene Corp 骨髓增生异常综合征, 急性髓细胞样白血病 详情
BR-105 BR105 临床一期 海正生物制药有限公司, 浙江博锐生物制药有限公司 肿瘤 详情

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