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SIRP alpha信息

英文名称:Signal-regulatory protein alpha
中文名称:信号调节蛋白α
靶点别称:SHPS-1,Macrophage fusion receptor,Brain Ig-like molecule with tyrosine-based activation motifs,MFR,Signal-regulatory protein alpha-1,Signal-regulatory protein alpha-2,CD172a,MyD-1 antigen,Sirp-alpha-3,MYD1,SIRPA,Signal Regulatory Protein Alpha,CD172 Antig
上市药物数量:1
临床药物数量:4
最高研发阶段:批准上市

SIRP alpha产品列表

 
评论(4)
SIA-M52H4|Mouse SIRP alpha / CD172a Protein, His Tag
  1. 156XXXXXXX8
  2. 0人赞
  3. 采购的蛋白用于开展动物免疫工作,经过验证能够与SIRP阿尔法的抗体结合,现已顺利运用到羊驼免疫工作上。
  4. 2021-02-19
CDA-H82F2|Biotinylated Human SIRP alpha / CD172a Protein, Fc,Avitag™ (MALS verified)
  1. 178XXXXXXX3
  2. 2人赞
  3. 我们公司购买的CD172蛋白,用于生物活性放行产品的检测。这个蛋白性能稳定,检测结果数据稳定,而且公司发货速度较快。
  4. 2019-10-11
CDA-H82F2|Biotinylated Human SIRP alpha / CD172a Protein, Fc,Avitag™ (MALS verified)
  1. 135XXXXXXX4
  2. 1人赞
  3. 我们公司购买的CD172蛋白,用于生物活性方法放行的检测。厂家发货速度,收到货易于保存。这个蛋白性能稳定。
  4. 2019-10-11
 

SIRP alpha Molecule Synonym Name

SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1

SIRP alpha 分子背景

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

SIRP alpha 参考文献

SIRP alpha上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Elagolix/estradiol/norethindrone acetate 批准上市 艾伯维 Oriahnn United States 月经过多 Abbvie Inc 2020-05-29 月经过多

SIRP alpha临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CC-95251 CC-95251 临床一期 Celgene Corp 血液肿瘤
ALX-148 ALX148; ALX-148 临床二期 Alexo Therapeutics 头颈癌, 实体瘤, 头颈部鳞状细胞癌, 骨髓增生异常综合征, 非霍奇金淋巴瘤, 急性髓细胞样白血病, 转移癌 详情
BI-765063 OSE-172; BI-765063 临床一期 Ose Immunotherapeutics 实体瘤 详情

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