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SIRP alpha信息

英文名称:Signal-regulatory protein alpha
中文名称:信号调节蛋白α
靶点别称:SHPS-1,Macrophage fusion receptor,Brain Ig-like molecule with tyrosine-based activation motifs,MFR,Signal-regulatory protein alpha-1,Signal-regulatory protein alpha-2,CD172a,MyD-1 antigen,Sirp-alpha-3,MYD1,SIRPA,Signal Regulatory Protein Alpha,CD172 Antigen-Like Family Member A,Inhibitory Receptor SHPS-1,PTPNS1,SHPS1,SIRP,P84,Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs,Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1,Tyrosine-Protein Phosphatase Non-Recept
上市药物数量:2
临床药物数量:7
最高研发阶段:批准上市

SIRP alpha产品列表

 
评论(23)
CDA-H82F2|Biotinylated Human SIRP alpha / CD172a Protein, Fc,Avitag™ (MALS verified)
  1. 198XXXXXXX6
  2. 0人赞
  3. 利用生物素-链霉亲和素系统的高特异性和高灵敏度特性,您可将生物素化蛋白固定在链霉亲和素包被96孔板上以应用于各类实验,与非生物素体系相比检测速度更快、结合能力更强、非特异背景更低。
  4. 2022-05-16
SIA-HP252|PE-Labeled Human SIRP alpha / CD172a Protein, Fc Tag (recommended for neutralizing assay)
  1. 134XXXXXXX6
  2. 0人赞
  3. 用于体内体外binding assay,这个蛋白稳定性好,特异性强,荧光素稳定
  4. >
  5. 2022-03-16
SIA-M5258|Mouse SIRP alpha / CD172a Protein, Fc Tag (MALS verified)
  1. 134XXXXXXX6
  2. 0人赞
  3. 客户化合物处理细胞之后,与mouse SIRPa结合,然后用流式检测结合效果。建议:希望能定制mouse SIRPa-PE的蛋白
  4. >
  5. 2022-02-24
 

SIRP alpha 分子别名

SIRP alpha,SHPS1,SIRPA,CD172A,BIT,SHPS-1,MFR,MYD-1,MYD1,PTPNS1,SIRPalpha,p84,SIRP-alpha,CD172

SIRP alpha 分子背景

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

SIRP alpha 前沿进展

SIRP alpha上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Relugolix/Estradiol/Norethindrone Acetate 批准上市 Myovant Sciences MYFEMBREE United Kingdom 子宫肿瘤 Gedeon Richter 2021-05-26 平滑肌瘤, 子宫肿瘤, 月经过多 详情
Elagolix/estradiol/norethindrone acetate 批准上市 艾伯维 Oriahnn United States 月经过多 Abbvie Inc 2020-05-29 月经过多 详情

SIRP alpha临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
BI-765063 OSE-172; BI-765063 临床一期 Ose Immunotherapeutics 实体瘤, 头颈部鳞状细胞癌, 黑色素瘤, 非小细胞肺癌 详情
SL-172154 SL-172154 临床一期 Shattuck Labs Inc 卵巢癌, 头颈部鳞状细胞癌, 腹膜癌, 鳞状细胞癌, 输卵管癌 详情
RRx-001 ABDNAZ; RRx-001 临床三期 Epicentre Biotechnologies Llc 实体瘤, 胶质母细胞瘤, 卵巢上皮癌, 小细胞肺癌, 中枢神经系统肿瘤, 少突神经胶质瘤, 神经内分泌瘤, 脑癌, 胆管上皮癌, 结直肠癌, 淋巴瘤, 小细胞癌, 脑转移, 非小细胞肺癌, 转移癌, 口腔炎 详情
[89Zr]Zr- BI-765063(Boehringer Ingelheim) 临床一期 Boehringer Ingelheim Corp 头颈部鳞状细胞癌, 黑色素瘤, 非小细胞肺癌 详情
BR-105 BR105 临床一期 海正生物制药有限公司 肿瘤 详情
GS-0189 GS-0189; FSI-189 临床一期 Gilead Sciences Inc 非霍奇金淋巴瘤 详情
CC-95251 CC-95251 临床一期 Celgene Corp 血液肿瘤, 骨髓增生异常综合征, 急性髓细胞样白血病 详情
AL-008 AL-008; IBI-397 临床一期 Alector 肿瘤 详情

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