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IL-1 alpha信息

英文名称:Interleukin-1 alpha
中文名称:白细胞介素-1α
靶点别称:Interleukin-1 Alpha,IL1A,IL1F1,IL-1 alpha,Interleukin 1 Alpha,Hematopoietin-1,Pro-Interleukin-1-Alpha,Preinterleukin 1 Alpha,IL1-ALPHA,IL-1A,IL1,Interleukin-1alpha
上市药物数量:1
临床药物数量:6
最高研发阶段:批准上市

IL-1 alpha 分子别名

IL1A,IL-1 ALPHA,IL1F1,IL1α

IL-1 alpha 分子背景

Interleukin-1 alpha (IL1a) is also known as IL-1A, IL1, IL1-ALPHA,IL1F1,and is a cytokine of the interleukin-1 family. IL1a possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. IL-1α is constitutively produced by epithelial cells. It is found in substantial amounts in normal human epidermis and is distributed in a 1:1 ratio between living epidermal cells and stratum corneum.The constitutive production of large amounts of IL-1α precursor by healthy epidermal keratinocytes interfere with the important role of IL-1α in immune responses, assuming skin as a barrier, which prevents the entry of pathogenic microorganisms into the body. In vitro, IL-1α possesses biological effect on cells in the picomolar to femtomolar range. In vivo, Shortly after an onset of an infection into organism, IL-1α activates a set of immune system response processes.

IL-1 alpha 前沿进展

IL-1 alpha上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Rilonacept 列洛西普 KPL-914; RGN-303 批准上市 Regeneron Pharmaceuticals Inc Arcalyst United States Cryopyrin蛋白相关周期性综合征 Regeneron Pharmaceuticals Inc 2008-02-27 心包炎, 慢性肾功能不全, 炎性疾病, 痛风, 弥漫性硬皮病, 荨麻疹, Cryopyrin蛋白相关周期性综合征, 神经性听力损失, 遗传病, 家族性地中海热, 幼年型类风湿性关节炎, 白介素受体拮抗剂缺乏症, 穆-韦二氏综合征, 系统性硬皮病, 贫血, 施尼茨勒综合征, 一型糖尿病, 成人斯蒂尔病 详情

IL-1 alpha临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AC-701 AC-701 临床二期 安成国际药业股份有限公司 酒渣鼻, 皮疹 详情
lutikizumab ABT-981 临床二期 艾伯维 膝关节炎, 化脓性汗腺炎, 骨关节炎 详情
Bermekimab T2-18C3; RA-18C3; CV-18C3; CA-18C3; MABP-1; MABp1; JNJ-77474462; MAB-p1 临床二期 Xbiotech Inc 寻常痤疮, 血液肿瘤, 坏疽性脓皮病, 二型糖尿病, 消化系统疾病, 肿瘤, 系统性硬皮病, 银屑病, 结直肠癌, 化脓性汗腺炎, 特应性皮炎, 湿疹 详情
Vilamakitug XB-2001 临床二期 Xbiotech Inc 胰腺癌, 类风湿关节炎, 风湿性疾病 详情
Tadekinig alfa (AB2 Bio) 临床三期 Ab2 Bio Ltd 巨噬細胞活化症候群, 细胞因子释放综合征, 噬血细胞性淋巴组织细胞增多症 详情
Hutrukin 临床一期 Xbiotech Inc 详情

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