Semaphorin 4D 靶点蛋白|抗体药物|临床药物信息

Semaphorin 4D信息

英文名称：Semaphorin 4D
中文名称：脑信号蛋白4D
靶点别称：SEMAJ，SEMA4D，Semaphorin 4D，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， (Semaphorin) 4D，C9orf164，CD100，BB18，GR3，A8，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， 4D，Chromosome 9 Open Reading Frame 164，CD100 Antigen，M-Sema-G，M-Sema G，Coll-4，COLL4，FLJ39737，Semaphorin-4D

上市药物数量：0
临床药物数量：1
最高研发阶段：临床二期

Semaphorin 4D产品列表

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在线 (1)

物种

Human (1)

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Fc Tag (1)

属性

Protein (1)

标记

Unconjugated (1)

货号	物种	产品描述	蛋白结构	纯度	活性
CD0-H5257	Human	Human Semaphorin 4D / SEMA4D / CD100 Protein, Fc Tag

Semaphorin 4D 分子别名

SEMA4D,C9orf164,CD100,FLJ33485,FLJ34282,FLJ39737,FLJ46484,M-sema-G,MGC169138,MGC169141,SEMAJ,coll-4,Semaphorin-4D

Semaphorin 4D 分子背景

Cluster of Differentiation 100 (CD100) is also known as Semaphorin-4D (SEMA4D), is a single-pass type I membrane protein which belongs to the semaphorin family, and is a human 150-kDa homodimer expressed at the surface of most hemopoietic cells. Semaphorin genes encode soluble and membrane-bound proteins, most of which have been shown to act as chemorepellents on growth cone guidance. CD100 is discrete, as it is a transmembrane leukocyte surface molecule that can also exist in a soluble form. Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation. It is involved in oligodendrogenesis during development and during recovery from ischemic injury.

Semaphorin 4D 前沿进展

Semaphorin 4D临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Pepinemab	VX-15; VX-15/2503; moAb VX-15/2503	临床二期	Vaccinex Inc	实体瘤, 头颈部鳞状细胞癌, 结肠癌, 胰腺癌, 多发性硬化, 乳腺癌, 骨肉瘤, 亨廷顿舞蹈症, 结直肠癌, 阿尔茨海默病, 黑色素瘤, 非小细胞肺癌	详情

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Semaphorin 4D