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 > 【S100B】

S100B信息

英文名称:Protein Nef
中文名称:HIV-1 Nef蛋白
靶点别称:nef,Negative factor,3'ORF,Protein Nef,F-protein
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

S100B产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
S1B-H5143
Human
Human S100B Protein, His Tag
ACRO质量管理体系
 
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S100B 分子别名

S100B,NEF,S100,S100beta

S100B 分子背景

S-100 protein beta chain (S100B),a member of the S-100 family, is also known as S-100 protein subunit beta and S100 calcium-binding protein B, which contains two EF-hand domains. S100B can weakly bind calcium but bind zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Also, S100B can bind to and initiate the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction,S100B may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Fuethermore,S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. S100B may mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

S100B 前沿进展

S100B临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
HIV clade B mRNA dendritic cell therapy (Immunomic Therapeutics/Universite Libre de Bruxelles) 临床一期 Immunomic Therapeutics Inc HIV感染 详情

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