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GM-CSF信息

英文名称:Macrophage colony stimulating factor 2
中文名称:巨噬细胞集落刺激因子2
靶点别称:GM-CSF,Molgramostin,CSF2,Colony Stimulating Factor 2,Sargramostim,GMCSF,CSF,Granulocyte Macrophage-Colony Stimulating Factor,Granulocyte-Macrophage Colony Stimulating Factor,Colony-Stimulating Factor,Granulocyte-Macrophage Colony-Stimulating Factor,Colony Stimulating Factor 2 (Granulocyte-Macrophage),Molgramostim
上市药物数量:0
临床药物数量:9
最高研发阶段:申请上市

GM-CSF产品列表

 
评论(3)
GMF-H4214|Human GM-CSF Protein, premium grade
  1. 134XXXXXXX9
  2. 1人赞
  3. 用这一款产品主要是进行GM-CSF的结合ELISA实验,GM-CSF的市面上的产品批间差都有些大,每换一个批次都要做一下方法的确认。ACRO的这一款是被我们美国客户认可的,批间差不大,实验结果也很稳定。
  4. >
  5. 2022-01-05
GMF-H8214|Biotinylated Human GM-CSF, epitope tag free, ultra sensitivity (primary amine labeling)
  1. 185XXXXXXX0
  2. 1人赞
  3. 该产品用于药物发现高通量筛选, ACRO的GM-CSF与其受体具有很好的亲和力,通过SA捕获0.0625ug/ml GM-CSF,可检测4-60ng/ml GM-CSFR,能够建立稳定的筛选体系,FRET同样具有较高的亲和力。
  4. 2021-09-05
GMF-H4214|Human GM-CSF Protein, premium grade
  1. 182XXXXXXX6
  2. 0人赞
  3. 是第一次通过朋友推荐买该货号重组蛋白,拿到之后做了Elisa亲和力测试,亲和力高,结果稳定性极好,相比市面其他同类产品性价比高,值得购买。
  4. >
  5. 2022-08-11
 

GM-CSF 分子别名

GM-CSF,CSF2,MGC131935

GM-CSF 分子背景

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is also known as Colony stimulating factor 2 (granulocyte-macrophage), is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells, and is secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts. GM-CSF is a cytokine that functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes exitthe circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells. Thus, it is part of the immune/inflammatory cascade, by which activation of a small number of macrophages can rapidly lead to an increase in their numbers, a process crucial for fighting infection. The active form of the protein is found extracellularly as a homodimer. Human GM-CSF glycosylated in its mature form. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIV-infected patients. The preliminary results have been promising. GM-CSF is also used as a medication to stimulate the production of white blood cells following chemotherapy.

GM-CSF 前沿进展

GM-CSF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
PBI-1402 PBI-1402 临床二期 Prometic Life Sciences 贫血 详情
PD-360324 PD-360324; PD-0360324 辉瑞制药有限公司 详情
Plonmarlimab TJ-003234RAR101; TJM-2; TJ-003234 临床二期 天境生物科技(上海)有限公司 新型冠状病毒肺炎, 类风湿关节炎 详情
SAR-441000 SAR441000; SAR-441000; BNT-131 Biontech Se, 赛诺菲 详情
Namilumab MT-203; AMG-203; IZN-101 Takeda Pharmaceutical Co Ltd, 安进 详情
Pexastimogene devacirepvec TG-6006; JX-594 临床二期 Sillajen, Regeneron Pharmaceuticals Inc, 美国国立癌症研究所, Samsung Medical Center & Samsung Electronics Devices Llc 尤因肉瘤, 转移癌, 黑色素瘤, 肝细胞癌, 淋巴瘤, 肺癌, 结直肠癌, 肉瘤, 乳腺癌, 肝癌, 神经母细胞瘤, 肿瘤, 肾母细胞瘤, 头颈部鳞状细胞癌, 肾细胞癌, 实体瘤, 横纹肌肉瘤 详情
Vusolimogene oderparepvec RP-1 临床二期 Replimune 皮肤黑色素瘤, 基底细胞癌, Merkel细胞癌, 皮肤肿瘤, 肿瘤, 微卫星不稳定, 鳞状细胞癌, 黑色素瘤, 非小细胞肺癌 详情
Gimsilumab MORAb-022; KIN-1901 临床二期 Morphotek 类风湿关节炎, 新型冠状病毒肺炎, 风湿性疾病, 炎性疾病 详情
BT-001 BT-001 临床二期 Transgene 实体瘤, Merkel细胞癌, 肿瘤, 三阴性乳腺肿瘤, 肉瘤, 转移癌, 非小细胞肺癌, 黑色素瘤 详情
Otilimab MOR-04357; GSK-3196165; GSK-165; MOR-103 临床三期 墨尔本大学 类风湿关节炎, 椎关节炎, 多发性硬化, 严重急性呼吸系统综合征, 骨关节炎 详情
Bi-shRNAfurin and GMCSF augmented autologous tumor cell immunotherapy (Gradalis/Mary Crowley) IND-14205 临床三期 Gradalis 卵巢癌, 肝癌, 结肠癌, 乳腺癌, 尤因肉瘤, 腹膜癌, 女性生殖系统癌症, 子宫肿瘤, 输卵管癌, 子宫内膜癌, 肺癌, 宫颈癌, 非小细胞肺癌, 黑色素瘤 详情

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