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GM-CSF信息

英文名称:Macrophage colony stimulating factor 2
中文名称:巨噬细胞集落刺激因子2
靶点别称:GM-CSF,Molgramostin,CSF2,Colony Stimulating Factor 2,Sargramostim,GMCSF,CSF,Granulocyte Macrophage-Colony Stimulating Factor,Granulocyte-Macrophage Colony Stimulating Factor,Colony-Stimulating Factor,Granulocyte-Macrophage Colony-Stimulating Factor,Colony Stimulating Factor 2 (Granulocyte-Macrophage),Molgramostim
上市药物数量:0
临床药物数量:9
最高研发阶段:申请上市

GM-CSF产品列表

 
评论(2)
GMF-H4214|ActiveMax® Human GM-CSF Protein, Tag Free
  1. 134XXXXXXX9
  2. 1人赞
  3. 用这一款产品主要是进行GM-CSF的结合ELISA实验,GM-CSF的市面上的产品批间差都有些大,每换一个批次都要做一下方法的确认。ACRO的这一款是被我们美国客户认可的,批间差不大,实验结果也很稳定。
  4. >
  5. 2022-01-05
GMF-H8214|Biotinylated Human GM-CSF, epitope tag free, ultra sensitivity (primary amine labeling)
  1. 185XXXXXXX0
  2. 1人赞
  3. 该产品用于药物发现高通量筛选, ACRO的GM-CSF与其受体具有很好的亲和力,通过SA捕获0.0625ug/ml GM-CSF,可检测4-60ng/ml GM-CSFR,能够建立稳定的筛选体系,FRET同样具有较高的亲和力。
  4. 2021-09-05
 

GM-CSF 分子别名

GM-CSF,CSF2,MGC131935

GM-CSF 分子背景

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is also known as Colony stimulating factor 2 (granulocyte-macrophage), is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells, and is secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts. GM-CSF is a cytokine that functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes exitthe circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells. Thus, it is part of the immune/inflammatory cascade, by which activation of a small number of macrophages can rapidly lead to an increase in their numbers, a process crucial for fighting infection. The active form of the protein is found extracellularly as a homodimer. Human GM-CSF glycosylated in its mature form. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIV-infected patients. The preliminary results have been promising. GM-CSF is also used as a medication to stimulate the production of white blood cells following chemotherapy.

GM-CSF 前沿进展

GM-CSF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Otilimab MOR-103; MOR-04357; GSK-3196165; GSK-165 临床三期 墨尔本大学 类风湿关节炎, 多发性硬化, 严重急性呼吸系统综合征, II型糖原贮积症, 骨关节炎 详情
BT-001 BT-001 临床二期 Transgene 实体瘤, Merkel细胞癌, 三阴性乳腺肿瘤, 肿瘤, 肉瘤, 非小细胞肺癌, 转移癌, 黑色素瘤 详情
PBI-1402 PBI-1402 临床二期 Prometic Life Sciences 贫血 详情
PD-360324 PD-360324; PD-0360324 临床二期 辉瑞制药有限公司 肿瘤, 皮肤红斑狼疮, 肺结节病 详情
Plonmarlimab TJ-003234RAR101; TJM-2; TJ-003234 临床三期 天境生物科技(上海)有限公司 新型冠状病毒肺炎, 类风湿关节炎 详情
Gimsilumab MORAb-022; KIN-1901 临床二期 Morphotek 新型冠状病毒肺炎, 类风湿关节炎, 鼻咽肿瘤, 风湿性疾病, 炎性疾病 详情
Pexastimogene devacirepvec TG-6006; JX-594 临床三期 Sillajen, Regeneron Pharmaceuticals Inc, 美国国立癌症研究所, Samsung Medical Center & Samsung Electronics Devices Llc 肝癌, 横纹肌肉瘤, 肾细胞癌, 头颈部鳞状细胞癌, 肾母细胞瘤, 神经母细胞瘤, 尤因肉瘤, 结直肠癌, 肺癌, 淋巴瘤, 肝细胞癌, 黑色素瘤 详情
Bi-shRNAfurin and GMCSF augmented autologous tumor cell immunotherapy (Gradalis/Mary Crowley) IND-14205 临床三期 Gradalis 卵巢癌, 肝癌, 结肠癌, 尤因肉瘤, 乳腺癌, 女性生殖系统癌症, 肺癌, 子宫肿瘤, 黑色素瘤, 非小细胞肺癌, 宫颈癌 详情
Namilumab MT-203; AMG-203; IZN-101 临床二期 Takeda Pharmaceutical Co Ltd, 安进 强直性脊柱炎, 类风湿关节炎, 银屑病 详情
Vusolimogene oderparepvec RP-1 临床二期 Replimune 皮肤黑色素瘤, Merkel细胞癌, 皮肤肿瘤, 基底细胞痣综合征, 微卫星不稳定, 鳞状细胞癌, 黑色素瘤, 非小细胞肺癌 详情
SAR-441000 SAR441000; SAR-441000; BNT-131 临床一期 Biontech Se, 赛诺菲 转移癌 详情

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