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GM-CSF信息

英文名称:Macrophage colony stimulating factor 2
中文名称:巨噬细胞集落刺激因子2
靶点别称:Molgramostim,Granulocyte-Macrophage Colony Stimulating Factor,Colony-Stimulating Factor,Granulocyte-Macrophage Colony-Stimulating Factor,GM-CSF,Molgramostin,CSF2,Colony Stimulating Factor 2,Sargramostim,GMCSF,CSF,Granulocyte Macrophage-Colony Stimulating
上市药物数量:0
临床药物数量:7
最高研发阶段:临床三期

GM-CSF产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
GMF-H8214
Human
Biotinylated Human GMCSF Protein,HEK293 Expressed
GMF-H4214
Human
ActiveMax® Human GM-CSF Protein, Tag Free
 
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GM-CSF 分子别名

GM-CSF,CSF2,MGC131935

GM-CSF 分子背景

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is also known as Colony stimulating factor 2 (granulocyte-macrophage), is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells, and is secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts. GM-CSF is a cytokine that functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes exitthe circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells. Thus, it is part of the immune/inflammatory cascade, by which activation of a small number of macrophages can rapidly lead to an increase in their numbers, a process crucial for fighting infection. The active form of the protein is found extracellularly as a homodimer. Human GM-CSF glycosylated in its mature form. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIV-infected patients. The preliminary results have been promising. GM-CSF is also used as a medication to stimulate the production of white blood cells following chemotherapy.

GM-CSF 参考文献

GM-CSF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Otilimab MOR-103; MOR-04357; GSK-3196165; GSK-165 临床三期 墨尔本大学 类风湿关节炎, 多发性硬化, 严重急性呼吸系统综合征, 骨关节炎 详情
Gimsilumab MORAb-022 临床二期 Morphotek 类风湿关节炎, 新型冠状病毒肺炎, 鼻咽肿瘤 详情
Namilumab MT-203; AMG-203; IZN-101 临床二期 Takeda Pharmaceutical Co Ltd, 安进 类风湿关节炎, 强直性脊柱炎, 银屑病 详情
TJ-003234 TJM-2; TJ-003234; TJ-003234RAR101 临床三期 天境生物科技(上海)有限公司 新型冠状病毒肺炎, 类风湿关节炎 详情
PD-360324 PD-360324; PD-0360324 临床二期 辉瑞制药有限公司 肿瘤, 皮肤红斑狼疮, 肺结节病 详情
PBI-1402 PBI-1402 临床二期 Prometic Life Sciences 贫血
Lenzilumab KB-003 临床三期 Kalobios B-细胞淋巴瘤, 新型冠状病毒肺炎, 慢性骨髓单核细胞性白血病, 类风湿关节炎 详情

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