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P-Selectin信息
英文名称：P-selectin
中文名称：P-选择素
靶点别称：Platelet Activation Dependent Granule-External Membrane Protein，Granule Membrane Protein 140kDa，PADGEM，GRMP，Selectin P (Granule Membrane Protein 140kD， Antigen CD62)，Platelet Alpha-Granule Membrane Protein，Granulocyte Membrane Protein，CD62P Antigen，Antigen CD62，P-Selectin，GMP140，CD62P，CD62，PSEL，LECAM3，CD62 antigen-like family member P，GMRP，GMP-140，Granule membrane protein 140，SELP，Selectin P，Selectin P (Granule Membrane Protein 140kDa， Antigen CD62)，Leukocyte-Endothelial Cell Adhesion Molecule 3
中文名称：P-选择素
靶点别称：Platelet Activation Dependent Granule-External Membrane Protein，Granule Membrane Protein 140kDa，PADGEM，GRMP，Selectin P (Granule Membrane Protein 140kD， Antigen CD62)，Platelet Alpha-Granule Membrane Protein，Granulocyte Membrane Protein，CD62P Antigen，Antigen CD62，P-Selectin，GMP140，CD62P，CD62，PSEL，LECAM3，CD62 antigen-like family member P，GMRP，GMP-140，Granule membrane protein 140，SELP，Selectin P，Selectin P (Granule Membrane Protein 140kDa， Antigen CD62)，Leukocyte-Endothelial Cell Adhesion Molecule 3
上市药物数量：1
临床药物数量：2
最高研发阶段：批准上市
临床药物数量：2
最高研发阶段：批准上市
P-Selectin产品列表
| 货号 | 物种 | 产品描述 | 蛋白结构 | 纯度 | 活性 |
|---|---|---|---|---|---|
| SEP-H52E4 |
 Human |
Human P-Selectin / CD62P Protein, His Tag |
 |
  |
|
| SEP-H5255 |
Human |
Human P-Selectin / CD62P Protein, Fc Tag |
 |
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P-Selectin 分子别名
P-Selectin,CD62P,SELP,GMP-140
P-Selectin 分子背景
P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM). SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets SELP is stored in α-granules. The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan. Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.
P-Selectin 前沿进展
P-Selectin上市药物信息
| 英文名称 | 中文名称 | 研发代码 | 研发阶段 | 公司 | 最早商品名 | 最早批准国家 | 最早适应症 | 最早批准公司 | 最早批准日期 | 适应症 | 临床试验 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Crizanlizumab | Sel-G-1; SEG-101; Sel-G1 | 批准上市 | 诺华制药, Selexys | Adakveo | EU | 镰状细胞血症 | Novartis Europharm Ltd | 2019-11-15 | 新型冠状病毒肺炎, 脑白质病, 阴茎异常勃起, 骨髓纤维化, 镰状细胞血症 | 详情 |
