P-Selectin 靶点蛋白|抗体药物|临床药物信息

P-Selectin信息

英文名称：P-selectin
中文名称：P-选择素
靶点别称：Platelet Activation Dependent Granule-External Membrane Protein，Granule Membrane Protein 140kDa，PADGEM，GRMP，Selectin P (Granule Membrane Protein 140kD， Antigen CD62)，Platelet Alpha-Granule Membrane Protein，Granulocyte Membrane Protein，CD62P Antigen，Antigen CD62，P-Selectin，GMP140，CD62P，CD62，PSEL，LECAM3，CD62 antigen-like family member P，GMRP，GMP-140，Granule membrane protein 140，SELP，Selectin P，Selectin P (Granule Membrane Protein 140kDa， Antigen CD62)，Leukocyte-Endothelial Cell Adhesion Molecule 3

上市药物数量：1
临床药物数量：2
最高研发阶段：批准上市

P-Selectin产品列表

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产品库

在线 (2)

物种

Human (2)

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属性

Protein (2)

标记

Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
SEP-H52E4	Human	Human P-Selectin / CD62P Protein, His Tag
SEP-H5255	Human	Human P-Selectin / CD62P Protein, Fc Tag

P-Selectin 分子别名

P-Selectin,CD62P,SELP,GMP-140

P-Selectin 分子背景

P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM). SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets SELP is stored in α-granules. The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan. Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.

P-Selectin 前沿进展

P-Selectin上市药物信息

英文名称	中文名称	研发代码	研发阶段	公司	最早商品名	最早批准国家	最早适应症	最早批准公司	最早批准日期	适应症	临床试验
Crizanlizumab		Sel-G-1; SEG-101; Sel-G1	批准上市	诺华制药, Selexys	Adakveo	EU	镰状细胞血症	Novartis Europharm Ltd	2019-11-15	新型冠状病毒肺炎, 脑白质病, 阴茎异常勃起, 骨髓纤维化, 镰状细胞血症	详情

P-Selectin临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Dociparstat sodium	ODSH; CX-01; PGX-100; PGX-ODSH-2013-AML-1		Paringenix		详情
Inclacumab	RG-1512; RO-4905417; LC-1004-002; DSM-ACC-2641; R-1512	临床三期	罗氏, Genmab	心肌梗塞, 疼痛, 血管移植物阻塞, 外周动脉疾病, 镰状细胞血症	详情

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P-Selectin