PH20 靶点蛋白|抗体药物|临床药物信息

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在线 (2)

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Human (2)

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Protein (2)

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Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
PH0-H5225	Human	Human PH20 / SPAM1 Protein, His Tag (active enzyme) DMF Filed
PH0-H5219	Human	Human PH20 / SPAM1 Protein, Tag Free (active enzyme, MALS verified)

PH20 分子别名

SPAM1,PH-20,HYAL3,HYA1,HYAL1,HYAL5,SPAG15

PH20 分子背景

Hyaluronidase PH-20 is also known as Sperm adhesion molecule 1 (SPAM1) and Sperm surface protein PH-20, which belongs to the glycosyl hydrolase 56 family, SPAM1 / PH-20 is expressed in testis. SPAM-1 / PH20 random hydrolysis of (1->4)-linkages between N – acetyl – beta – D – glucosamine and D-glucuronate residues in hyaluronate. SPAM-1 / PH20 involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. SPAM1 aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.

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