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Noggin产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
NON-H5257
Human
ActiveMax® Human Noggin Protein, Fc Tag
NON-H5219
Human
Human Noggin Protein, Tag Free

ACROBiosystems提供将现有的目录Non-GMP级别(RUO或Premium级别)蛋白产品快速转化为GMP级别的升级服务,也可以从零开始为您提供GMP级别蛋白从头定制化开发服务>>点击立即咨询GMP级别蛋白产品定制服务~

 
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Noggin 分子别名

Noggin,NOG,SYM1,SYNS1

Noggin 分子背景

Noggin is also known as NOG, SYM1, SYNS1 and is a secreted homodimeric glycoprotein whose scaffold contains a cystine-knot topology similar to that of BMPs.Secreted Noggin probably remains close to the cell surface due to its binding of heparincontaining proteoglycans.Noggin inhibits TGF-β signal transduction by binding to TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion. During embryogenesis, Noggin antagonizes specific BMPs at defined times, for example, during neural tube, somite and cardiomyocyte growth and patterning. During skeletal development, Noggin prevents chondrocyte hyperplasia, thus allowing proper formation of joints. During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons Noggin also appears to maintain adult stem cell populations in vivo, for example, maintaining neural stem cells within the hippocampus.

Noggin 前沿进展

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