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Neprilysin信息

英文名称:Neprilysin
中文名称:脑啡肽酶
靶点别称:EC:3.4.24.11,EC 3.4.24,Atriopeptidase,NEP,SFE,Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase, CALLA, CD10),Membrane Metallo-Endopeptidase Variant 1,Membrane Metallo-Endopeptidase Variant 2,Neprilysin-390,Neprilysin-411,CD10 Antigen,EC 3.4.24.11,CMT2T,SCA43,EPN,MME,Enkephalinase,CALLA,Neutral endopeptidase,Common acute lymphocytic leukemia antigen,Neprilysin,CD10,Membrane Metalloendopeptidase,Neutral Endopeptidase 24.11,Skin fibroblast elastase
上市药物数量:2
临床药物数量:6
最高研发阶段:批准上市

Neprilysin产品列表

ACRO质量管理体系
 
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Neprilysin分子别名

MME,CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP,SFE,Neprilysin

Neprilysin分子背景

Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).

Neprilysin上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Racecadotril 消旋卡多曲 Tiorfan; Hidrasec 批准上市 Bioprojet Pharma France 腹泻 Bioprojet Pharma 1993-03-23 婴儿腹泻, 腹泻 详情
Sacubitril/Valsartan Sodium Hydrate 沙库巴曲/缬沙坦钠 LCZ-696 批准上市 诺华制药 Entresto, 诺欣妥 United States 心脏衰竭 Novartis Pharmaceuticals Corp 2015-07-07 乳腺癌, 左心室功能不全, 收缩性心力衰竭, 外周动脉疾病, 肥胖症, 淋巴瘤, 心脏和血管疾病, 肝功能衰退, 原发性高血压, 勃起功能障碍, 高血压, 新型冠状病毒感染, 肥大型心肌病, 心脏病, 心肌梗塞后综合征, 肾功能不全, 心肌梗塞, 心脏衰竭 详情

Neprilysin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Sacubitril AHU-377 临床二期 诺华制药 心脏衰竭, 肥大型心肌病, 胰岛素抵抗, 高血压, 代谢病, 原发性高血压, 心脏和血管疾病, 糖尿病 详情
Debio-0827 PL-37; Debio-0827 临床二期 Pharmaleads 疼痛 详情
Dexecadotril 临床三期 Bioprojet Pharma 胃肠疾病 详情
STR-324 STR-324 临床二期 中国科学院上海巴斯德研究所 急性疼痛 详情
QR-12000 QR-12000 临床二期 武汉朗来科技发展有限公司 高血压, 原发性高血压 详情

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