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Neprilysin信息

英文名称:Neprilysin
中文名称:脑啡肽酶
靶点别称:EC:3.4.24.11,MME,Enkephalinase,CALLA,Neutral endopeptidase,Common acute lymphocytic leukemia antigen,Neprilysin,CD10,Membrane Metalloendopeptidase,Neutral Endopeptidase 24.11,Atriopeptidase,NEP,SFE,Membrane Metallo-Endopeptidase (Neutral Endopeptidase, En
上市药物数量:2
临床药物数量:5
最高研发阶段:批准上市

Neprilysin产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
MME-H526a
Human
Human-MME-CD10-Protein-N-Fc-Tag
MME-H521b
Human
Human Neprilysin /CD10 Protein, Native
 
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Neprilysin 分子别名

MME,CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP,SFE,Neprilysin

Neprilysin 分子背景

Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).

Neprilysin 参考文献

Neprilysin上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Racecadotril 消旋卡多曲 Tiorfan; Hidrasec 批准上市 Bioprojet Pharma Mainland China 腹泻 Bioprojet Pharma 1993-03-23 婴儿腹泻, 腹泻 详情
Sacubitril/Valsartan Sodium Hydrate 沙库巴曲/缬沙坦钠 LCZ-696 批准上市 诺华制药 诺欣妥, Entresto Japan 心脏衰竭 Novartis Pharma Ag 2015-07-07 勃起功能障碍, 心脏衰竭, 肾功能不全, 心肌梗塞, 肥大型心肌病, 心肌梗塞后综合征, 高血压, 原发性高血压, 肝功能衰退, 淋巴瘤, 左心室功能不全, 收缩性心力衰竭 详情

Neprilysin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Dexecadotril 临床三期 Bioprojet Pharma 胃肠疾病
Sacubitril AHU-377 临床二期 诺华制药 心脏衰竭, 肥大型心肌病, 高血压, 原发性高血压 详情
Debio-0827 PL-37; Debio-0827 临床二期 Pharmaleads 疼痛
LHW-090 LHV-527; LHW-090 临床二期 诺华制药 高血压, 慢性肾功能不全 详情
Sacubitril/Allisartan Isoproxil S-086; AHU-377/EXP3174 临床二期 深圳信立泰药业股份有限公司 心脏衰竭, 高血压, 原发性高血压
STR-324 STR-324 临床二期 中国科学院上海巴斯德研究所 疼痛, 急性疼痛 详情

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