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MMP-2信息

英文名称:Matrix metalloproteinase-2
中文名称:基质金属蛋白酶-2
靶点别称:MMP-2,MMP2,Matrix metalloproteinase-2,72 kDa gelatinase,Matrix Metallopeptidase 2,CLG4A,TBE-1,Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase),Matrix Metalloproteinase 2,Matrix Metalloproteinase-II,72 KDa Type IV Coll
上市药物数量:1
临床药物数量:1
最高研发阶段:临床一期

MMP-2产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
MM2-H5225
Human
Human MMP-2 Protein, His Tag
MM2-M52H3
Mouse
Mouse MMP-2 Protein, His Tag
MM2-H82E3
Human
Biotinylated Human MMP-2 Protein, His,Avitag™
 
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MMP-2 分子别名

MMP2,CLG4,CLG4A,MMP-II,MONA,TBE-1

MMP-2 分子背景

Matrix metalloproteinase-2 (MMP-2) is also known as 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A and CLG4A, which belongs to the peptidase M10A family. MMP-2 / CLG4A contains 3 fibronectin type-II domains and 4 hemopexin-like domains. MMP-2 is produced by normal skin fibroblasts. MMP-2 cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln. MMP2 involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin.

MMP-2 参考文献

MMP-2上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验

MMP-2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AQU-005 AQU-005; NMAQU-005; NM-AQU-005 临床一期 Aquilus Pharmaceuticals 神经痛 详情

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