MMP-2 靶点蛋白|抗体药物|临床药物信息

MMP-2信息

英文名称：Matrix metalloproteinase-2
中文名称：基质金属蛋白酶-2
靶点别称：EC:3.4.24.24，Matrix Metallopeptidase 2 (Gelatinase A， 72kDa Gelatinase， 72kDa Type IV Collagenase)，MMP-2，MMP2，Matrix metalloproteinase-2，72 kDa gelatinase，Matrix Metallopeptidase 2，CLG4A，TBE-1，Matrix Metalloproteinase 2 (Gelatinase A， 72kDa Gelatinase， 72kDa Type IV Collagenase)，Matrix Metalloproteinase 2，Matrix Metalloproteinase-II，72 KDa Type IV Collagenase，Collagenase Type IV-A，Neutrophil Gelatinase，Gelatinase A，EC 3.4.24.24，MMP-II，MONA，CLG4，EC 3.4.24

上市药物数量：0
临床药物数量：1
最高研发阶段：临床一期

MMP-2产品列表

筛选结果

产品库

在线 (1)

物种

Mouse (1)

标签

His Tag (1)

属性

Protein (1)

标记

Unconjugated (1)

货号	物种	产品描述	蛋白结构	纯度	活性
MM2-M52H9	Mouse	Mouse MMP-2 (30-460) Protein, His Tag (active enzyme)

MM2-M52H9|Mouse MMP-2 (30-460) Protein, His Tag (active enzyme)

151XXXXXXX0

0人赞

使用该产品用于裂解多肽，在两小时，三十七摄氏度条件下，可以使得多肽裂解很充分，这里需要使用APMA提前活化该蛋白。protocol写的也很详细
2023-03-28

MMP-2分子别名

MMP2,CLG4,CLG4A,MMP-II,MONA,TBE-1

MMP-2分子背景

Matrix metalloproteinase-2 (MMP-2) is also known as 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A and CLG4A, which belongs to the peptidase M10A family. MMP-2 / CLG4A contains 3 fibronectin type-II domains and 4 hemopexin-like domains. MMP-2 is produced by normal skin fibroblasts. MMP-2 cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln. MMP2 involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin.

MMP-2临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
AQU-005	AQU-005; NMAQU-005; NM-AQU-005	临床一期	Aquilus Pharmaceuticals	神经痛	详情

会议日历

会议一览

MMP-2

MMP-2信息

MMP-2产品列表

MMP-2分子别名

MMP-2分子背景

MMP-2临床药物信息

新闻订阅

在线留言

消息提示