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MCAM信息

英文名称:Melanoma cell adhesion molecule
中文名称:黑色素瘤细胞粘附分子
靶点别称:METCAM,CD146,Melanoma cell adhesion molecule,MCAM,Cell surface glycoprotein MUC18,S-Endo 1 Endothelial-Associated Antigen,Melanoma-Associated Antigen MUC18,Melanoma-Associated Antigen A32,Gicerin,MUC18,CD146 Antigen,Cell surface glycoprotein P1H12,Melanoma Adhesion Molecule,MelCAM,HEMCAM
上市药物数量:0
临床药物数量:0
最高研发阶段:终止

MCAM 分子别名

MCAM,CD146,MUC18

MCAM 分子背景

CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle.CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells.As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.

MCAM 前沿进展

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