Leptin R 靶点蛋白|抗体药物|临床药物信息

Leptin R信息

英文名称：Leptin receptor
中文名称：瘦素受体
靶点别称：CD295，OB receptor，LEPR，HuB219，DB，Leptin Receptor，LEP-R，OB-R，OBR，CD295 Antigen，LEPRD，Receptors， Leptin

上市药物数量：1
临床药物数量：2
最高研发阶段：批准上市

Leptin R产品列表

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在线 (1)

物种

Human (1)

标签

Fc Tag (1)

属性

Protein (1)

标记

Unconjugated (1)

货号	物种	产品描述	蛋白结构	纯度	活性
LER-H5252	Human	Human- LEPR-CD295-Protein-C-Fc-Tag

Leptin R 分子别名

LEPR,CD295,DKFZp686B1731,OBR,Leptin receptor

Leptin R 分子背景

Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.

Leptin R 前沿进展

Leptin R上市药物信息

英文名称	中文名称	研发代码	研发阶段	公司	最早商品名	最早批准国家	最早适应症	最早批准公司	最早批准日期	适应症	临床试验
Metreleptin	美曲普汀	KTR-103; AC-164594	批准上市	Amylin Pharmaceutical, 百时美施贵宝, 阿斯利康	Metreleptin [SHIONOGI], Myalepta	EU	脂肪营养不良	Amryt Pharmaceuticals Dac	2013-03-25	HIV感染, 一型糖尿病, 非酒精性脂肪肝, 胰岛素抵抗, X综合征, 脂肪营养不良, 肥胖症, 家族局部性脂质营养不良, 先天性全身性脂肪营养不良, 多发性对称性脂肪瘤样病, 超重, 糖尿病, 高脂血症	详情

Leptin R临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
ERX-1000	ERX-1000	临床一期	ERX Pharmaceuticals Inc	肥胖症	详情
Mibavademab	REGN-4461	临床二期	Regeneron Pharmaceuticals Inc	先天性全身性脂肪营养不良, 家族局部性脂质营养不良, 脂类代谢紊乱	详情

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Leptin R